Interplay of lamin A and lamin B LADs on the radial positioning of chromatin

Interplay of lamin A and lamin B LADs on the radial positioning of chromatin

Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells. We show the existence of lamina-associated domains (LADs) interacting with lamin A,...

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Bibliographic Details
Main Authors: Frida Forsberg, Annaël Brunet, Tharvesh M. Liyakat Ali, Philippe Collas
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Nucleus
Subjects:
chromatin
lad
nuclear lamins
genome conformation
3d genome
Online Access:http://dx.doi.org/10.1080/19491034.2019.1570810

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