Potential effects of shift work on skin autoimmune diseases
Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000951/full |
| _version_ | 1828032598264250368 |
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| author | Sarah Stenger Hanna Grasshoff Jennifer Elisabeth Hundt Jennifer Elisabeth Hundt Tanja Lange Tanja Lange Tanja Lange |
| author_facet | Sarah Stenger Hanna Grasshoff Jennifer Elisabeth Hundt Jennifer Elisabeth Hundt Tanja Lange Tanja Lange Tanja Lange |
| author_sort | Sarah Stenger |
| collection | DOAJ |
| description | Shift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep impairment seem to be the key underlying mechanisms. Presumably, disturbances of the sleep-wake cycle also drive skin-specific autoimmune diseases, but epidemiological and experimental evidence so far is scarce. This review summarizes the effects of shift work, circadian misalignment, poor sleep, and the effect of potential hormonal mediators such as stress mediators or melatonin on skin barrier functions and on innate and adaptive skin immunity. Human studies as well as animal models were considered. We will also address advantages and potential pitfalls in animal models of shift work, and possible confounders that could drive skin autoimmune diseases in shift workers such as adverse lifestyle habits and psychosocial influences. Finally, we will outline feasible countermeasures that may reduce the risk of systemic and skin autoimmunity in shift workers, as well as treatment options and highlight outstanding questions that should be addressed in future studies. |
| first_indexed | 2024-04-10T15:07:57Z |
| format | Article |
| id | doaj.art-db460224fdd04a42a45830a5e41eb42c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T15:07:57Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-db460224fdd04a42a45830a5e41eb42c2023-02-14T20:01:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011310.3389/fimmu.2022.10009511000951Potential effects of shift work on skin autoimmune diseasesSarah Stenger0Hanna Grasshoff1Jennifer Elisabeth Hundt2Jennifer Elisabeth Hundt3Tanja Lange4Tanja Lange5Tanja Lange6Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, GermanyDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, GermanyLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, GermanyCenter for Research on Inflammation of the Skin, University of Lübeck, Lübeck, GermanyDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, GermanyCenter for Research on Inflammation of the Skin, University of Lübeck, Lübeck, GermanyCenter of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, GermanyShift work is associated with systemic chronic inflammation, impaired host and tumor defense and dysregulated immune responses to harmless antigens such as allergens or auto-antigens. Thus, shift workers are at higher risk to develop a systemic autoimmune disease and circadian disruption with sleep impairment seem to be the key underlying mechanisms. Presumably, disturbances of the sleep-wake cycle also drive skin-specific autoimmune diseases, but epidemiological and experimental evidence so far is scarce. This review summarizes the effects of shift work, circadian misalignment, poor sleep, and the effect of potential hormonal mediators such as stress mediators or melatonin on skin barrier functions and on innate and adaptive skin immunity. Human studies as well as animal models were considered. We will also address advantages and potential pitfalls in animal models of shift work, and possible confounders that could drive skin autoimmune diseases in shift workers such as adverse lifestyle habits and psychosocial influences. Finally, we will outline feasible countermeasures that may reduce the risk of systemic and skin autoimmunity in shift workers, as well as treatment options and highlight outstanding questions that should be addressed in future studies.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000951/fullshift workskinsleepcircadianautoimmunecortisol |
| spellingShingle | Sarah Stenger Hanna Grasshoff Jennifer Elisabeth Hundt Jennifer Elisabeth Hundt Tanja Lange Tanja Lange Tanja Lange Potential effects of shift work on skin autoimmune diseases Frontiers in Immunology shift work skin sleep circadian autoimmune cortisol |
| title | Potential effects of shift work on skin autoimmune diseases |
| title_full | Potential effects of shift work on skin autoimmune diseases |
| title_fullStr | Potential effects of shift work on skin autoimmune diseases |
| title_full_unstemmed | Potential effects of shift work on skin autoimmune diseases |
| title_short | Potential effects of shift work on skin autoimmune diseases |
| title_sort | potential effects of shift work on skin autoimmune diseases |
| topic | shift work skin sleep circadian autoimmune cortisol |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000951/full |
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