Selenium-Binding Protein 1 in Human Health and Disease
Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metab...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/19/11/3437 |
| _version_ | 1811281436130410496 |
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| author | Mostafa Elhodaky Alan M. Diamond |
| author_facet | Mostafa Elhodaky Alan M. Diamond |
| author_sort | Mostafa Elhodaky |
| collection | DOAJ |
| description | Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metabolism of sulfur-containing molecules. SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome. In this review, the transcriptional regulation of <i>SBP1</i>, the different physiological roles reported for SBP1, as well as the implications of SBP1 function in cancer and other diseases are presented. |
| first_indexed | 2024-04-13T01:32:29Z |
| format | Article |
| id | doaj.art-db46ca1bd1894b31948724a0ed43fad8 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T01:32:29Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-db46ca1bd1894b31948724a0ed43fad82022-12-22T03:08:28ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-11-011911343710.3390/ijms19113437ijms19113437Selenium-Binding Protein 1 in Human Health and DiseaseMostafa Elhodaky0Alan M. Diamond1Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USADepartment of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USASelenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds selenium. SBP1 may play important roles in several fundamental physiological functions, including protein degradation, intra-Golgi transport, cell differentiation, cellular motility, redox modulation, and the metabolism of sulfur-containing molecules. SBP1 expression is often reduced in many cancer types compared to the corresponding normal tissues and low levels of SBP1 are frequently associated with poor clinical outcome. In this review, the transcriptional regulation of <i>SBP1</i>, the different physiological roles reported for SBP1, as well as the implications of SBP1 function in cancer and other diseases are presented.https://www.mdpi.com/1422-0067/19/11/3437selenium-binding protein 1SBP1SELENBP1hSP56cancerdisease |
| spellingShingle | Mostafa Elhodaky Alan M. Diamond Selenium-Binding Protein 1 in Human Health and Disease International Journal of Molecular Sciences selenium-binding protein 1 SBP1 SELENBP1 hSP56 cancer disease |
| title | Selenium-Binding Protein 1 in Human Health and Disease |
| title_full | Selenium-Binding Protein 1 in Human Health and Disease |
| title_fullStr | Selenium-Binding Protein 1 in Human Health and Disease |
| title_full_unstemmed | Selenium-Binding Protein 1 in Human Health and Disease |
| title_short | Selenium-Binding Protein 1 in Human Health and Disease |
| title_sort | selenium binding protein 1 in human health and disease |
| topic | selenium-binding protein 1 SBP1 SELENBP1 hSP56 cancer disease |
| url | https://www.mdpi.com/1422-0067/19/11/3437 |
| work_keys_str_mv | AT mostafaelhodaky seleniumbindingprotein1inhumanhealthanddisease AT alanmdiamond seleniumbindingprotein1inhumanhealthanddisease |