ZNF768: controlling cellular senescence and proliferation with ten fingers

We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypa...

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Bibliographic Details
Main Authors: Romain Villot, Audrey Poirier, Romain Devillers, Aliona Kolnoguz, Sabine Elowe, Venkata S. K. Manem, Philippe Joubert, Frédérick A. Mallette, Mathieu Laplante
Format: Article
Language:English
Published: Taylor & Francis Group 2021-11-01
Series:Molecular & Cellular Oncology
Online Access:http://dx.doi.org/10.1080/23723556.2021.1985930