The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice

The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice

<i>MCPH1</i> is the first gene identified to be responsible for the human autosomal recessive disorder primary microcephaly (MCPH). Mutations in the N-terminal and central domains of MCPH1 are strongly associated with microcephaly in human patients. A recent study showed that the central...

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Bibliographic Details
Main Authors: Yaru Wang, Wen Zong, Wenli Sun, Chengyan Chen, Zhao-Qi Wang, Tangliang Li
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
microcephaly
MCPH1
central domain
brain development
gonad development
Online Access:https://www.mdpi.com/2073-4409/11/17/2715

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