Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway?
The word “microbiome” is a combination of “microbiota” and “genome,” which represents the genomic concept of microbiota. The bacterial culture method is the mainstay of identifying microbes, while polymerase chain reaction adds diagnostic value. However, in the era of next-generation sequencing, ach...
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| Format: | Article |
| Language: | English |
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Korean Society of Neonatology
2023-11-01
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| Series: | Neonatal Medicine |
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| Online Access: | http://neo-med.org/upload/pdf/nm-2023-30-4-96.pdf |
| _version_ | 1827596286104174592 |
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| author | Yong-Sung Choi |
| author_facet | Yong-Sung Choi |
| author_sort | Yong-Sung Choi |
| collection | DOAJ |
| description | The word “microbiome” is a combination of “microbiota” and “genome,” which represents the genomic concept of microbiota. The bacterial culture method is the mainstay of identifying microbes, while polymerase chain reaction adds diagnostic value. However, in the era of next-generation sequencing, achieving high-throughput microbiota footprints is extremely sensitive. This sensitivity often leads to confusion, as it can detect specific microbes genomes, even in sterile samples, such as blood, placenta, breast milk, skin, vagina, and stool. The neonatal microbiome remarkably influences both fetal and neonatal life related to health status and disease outcome. However, its origins pose a question: does it stem from a direct gateway or through a breakdown of barriers? This review provides a brief overview of evidence and speculative insights. |
| first_indexed | 2024-03-09T03:08:27Z |
| format | Article |
| id | doaj.art-db4a5957d39e49f7aeec52e46c29a892 |
| institution | Directory Open Access Journal |
| issn | 2287-9412 2287-9803 |
| language | English |
| last_indexed | 2024-03-09T03:08:27Z |
| publishDate | 2023-11-01 |
| publisher | Korean Society of Neonatology |
| record_format | Article |
| series | Neonatal Medicine |
| spelling | doaj.art-db4a5957d39e49f7aeec52e46c29a8922023-12-04T05:28:30ZengKorean Society of NeonatologyNeonatal Medicine2287-94122287-98032023-11-013049610110.5385/nm.2023.30.4.961090Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway?Yong-Sung ChoiThe word “microbiome” is a combination of “microbiota” and “genome,” which represents the genomic concept of microbiota. The bacterial culture method is the mainstay of identifying microbes, while polymerase chain reaction adds diagnostic value. However, in the era of next-generation sequencing, achieving high-throughput microbiota footprints is extremely sensitive. This sensitivity often leads to confusion, as it can detect specific microbes genomes, even in sterile samples, such as blood, placenta, breast milk, skin, vagina, and stool. The neonatal microbiome remarkably influences both fetal and neonatal life related to health status and disease outcome. However, its origins pose a question: does it stem from a direct gateway or through a breakdown of barriers? This review provides a brief overview of evidence and speculative insights.http://neo-med.org/upload/pdf/nm-2023-30-4-96.pdfmicrobiomeplacentainfant, newbornfetus |
| spellingShingle | Yong-Sung Choi Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? Neonatal Medicine microbiome placenta infant, newborn fetus |
| title | Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? |
| title_full | Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? |
| title_fullStr | Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? |
| title_full_unstemmed | Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? |
| title_short | Does Neonatal Microbiome Research Encompass the Placental Transfer Pathway? |
| title_sort | does neonatal microbiome research encompass the placental transfer pathway |
| topic | microbiome placenta infant, newborn fetus |
| url | http://neo-med.org/upload/pdf/nm-2023-30-4-96.pdf |
| work_keys_str_mv | AT yongsungchoi doesneonatalmicrobiomeresearchencompasstheplacentaltransferpathway |