Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients with Venous Thromboembolism
As one of the frequent complications leading to poor prognosis in hospitalized COVID-19 patients, a better understanding of venous thromboembolism (VTE) in COVID-19 patients is needed. We conducted a single-center, retrospective study on 96 COVID-19 patients admitted to the intensive care unit (ICU)...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-05-01
|
| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296231177676 |
| _version_ | 1797820131727900672 |
|---|---|
| author | Rundan Duan MD Qihong Ni PhD Yinan Li PhD Mingli Zhu PhD Wen Li PhD Peng Wang PhD Kai Yuan PhD Philipp von Hundelshausen MD Jingpu Zhu MM Lan Zhang PhD Lei Lv MM |
| author_facet | Rundan Duan MD Qihong Ni PhD Yinan Li PhD Mingli Zhu PhD Wen Li PhD Peng Wang PhD Kai Yuan PhD Philipp von Hundelshausen MD Jingpu Zhu MM Lan Zhang PhD Lei Lv MM |
| author_sort | Rundan Duan MD |
| collection | DOAJ |
| description | As one of the frequent complications leading to poor prognosis in hospitalized COVID-19 patients, a better understanding of venous thromboembolism (VTE) in COVID-19 patients is needed. We conducted a single-center, retrospective study on 96 COVID-19 patients admitted to the intensive care unit (ICU) from April to June 2022, in Shanghai Renji Hospital. Records of these COVID-19 patients upon admission were reviewed for demographic information, co-morbidities, vaccinations, treatment, and laboratory tests. VTE occurred in 11 (11.5%) cases among 96 COVID-19 patients despite the standard thromboprophylaxis since ICU admission. In COVID-VTE patients, a significant increase in B cells and a decrease in Ts cells were observed and a strong negative correlation ( r = −0.9524, P = .0003) was found between these two populations. In COVID-19 patients with VTE, increased MPV and decreased albumin levels were seen in addition to the common VTE indicators of D-dimer abnormalities. The altered lymphocyte composition in COVID-VTE patients is noteworthy. In addition to D-dimer, MPV and albumin levels might be novel indicators for the risk of VTE in COVID-19 patients. |
| first_indexed | 2024-03-13T09:32:51Z |
| format | Article |
| id | doaj.art-db4b67566ee44786b26758047d2e8ac9 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-03-13T09:32:51Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-db4b67566ee44786b26758047d2e8ac92023-05-25T21:33:20ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232023-05-012910.1177/10760296231177676Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients with Venous ThromboembolismRundan Duan MD0Qihong Ni PhD1Yinan Li PhD2Mingli Zhu PhD3Wen Li PhD4Peng Wang PhD5Kai Yuan PhD6Philipp von Hundelshausen MD7Jingpu Zhu MM8Lan Zhang PhD9Lei Lv MM10 Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University, Munich, Germany Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Critical Care Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaAs one of the frequent complications leading to poor prognosis in hospitalized COVID-19 patients, a better understanding of venous thromboembolism (VTE) in COVID-19 patients is needed. We conducted a single-center, retrospective study on 96 COVID-19 patients admitted to the intensive care unit (ICU) from April to June 2022, in Shanghai Renji Hospital. Records of these COVID-19 patients upon admission were reviewed for demographic information, co-morbidities, vaccinations, treatment, and laboratory tests. VTE occurred in 11 (11.5%) cases among 96 COVID-19 patients despite the standard thromboprophylaxis since ICU admission. In COVID-VTE patients, a significant increase in B cells and a decrease in Ts cells were observed and a strong negative correlation ( r = −0.9524, P = .0003) was found between these two populations. In COVID-19 patients with VTE, increased MPV and decreased albumin levels were seen in addition to the common VTE indicators of D-dimer abnormalities. The altered lymphocyte composition in COVID-VTE patients is noteworthy. In addition to D-dimer, MPV and albumin levels might be novel indicators for the risk of VTE in COVID-19 patients.https://doi.org/10.1177/10760296231177676 |
| spellingShingle | Rundan Duan MD Qihong Ni PhD Yinan Li PhD Mingli Zhu PhD Wen Li PhD Peng Wang PhD Kai Yuan PhD Philipp von Hundelshausen MD Jingpu Zhu MM Lan Zhang PhD Lei Lv MM Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients with Venous Thromboembolism Clinical and Applied Thrombosis/Hemostasis |
| title | Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients
with Venous Thromboembolism |
| title_full | Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients
with Venous Thromboembolism |
| title_fullStr | Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients
with Venous Thromboembolism |
| title_full_unstemmed | Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients
with Venous Thromboembolism |
| title_short | Lymphocytes, Mean Platelet Volume, and Albumin in Critically Ill COVID-19 Patients
with Venous Thromboembolism |
| title_sort | lymphocytes mean platelet volume and albumin in critically ill covid 19 patients with venous thromboembolism |
| url | https://doi.org/10.1177/10760296231177676 |
| work_keys_str_mv | AT rundanduanmd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT qihongniphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT yinanliphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT minglizhuphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT wenliphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT pengwangphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT kaiyuanphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT philippvonhundelshausenmd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT jingpuzhumm lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT lanzhangphd lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism AT leilvmm lymphocytesmeanplateletvolumeandalbuminincriticallyillcovid19patientswithvenousthromboembolism |