Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis
Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty acids, cytokines, and adipokines. The volume of BMAs increases along with age, osteoporosis and...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.902033/full |
| _version_ | 1811241611287330816 |
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| author | Yixuan Li Shan Cao Shan Cao Anastasia Gaculenko Yifan Zhan Aline Bozec Xiaoxiang Chen |
| author_facet | Yixuan Li Shan Cao Shan Cao Anastasia Gaculenko Yifan Zhan Aline Bozec Xiaoxiang Chen |
| author_sort | Yixuan Li |
| collection | DOAJ |
| description | Bone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty acids, cytokines, and adipokines. The volume of BMAs increases along with age, osteoporosis and/or obesity. With the rapid development of multi-omic analysis and the advance in in vivo imaging technology, further distinct characteristics and functions of BMAs have been revealed. There is accumulating evidence that BMAs are metabolically, biologically and functionally unique from white, brown, beige and pink adipocytes. Bone metastatic disease is an uncurable complication in cancer patients, where primary cancer cells spread from their original site into the bone marrow. Recent publications have highlighted those BMAs could also serve as a rich lipid source of fatty acids that can be utilized by the cancer cells during bone metastasis, particularly for breast, prostate, lung, ovarian and pancreatic cancer as well as melanoma. In this review, we summarize the novel progressions in BMAs metabolism, especially with multi-omic analysis and in vivo imaging technology. We also update the metabolic role of BMAs in bone metastasis, and their potential new avenues for diagnosis and therapies against metastatic cancers. |
| first_indexed | 2024-04-12T13:39:39Z |
| format | Article |
| id | doaj.art-db4c1ef1ca7a45babd0a18a9626939f6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T13:39:39Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-db4c1ef1ca7a45babd0a18a9626939f62022-12-22T03:30:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-06-011310.3389/fendo.2022.902033902033Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone MetastasisYixuan Li0Shan Cao1Shan Cao2Anastasia Gaculenko3Yifan Zhan4Aline Bozec5Xiaoxiang Chen6Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, GermanyDepartment of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, GermanyDrug Discovery, Shanghai Huaota Biopharmaceutical Co. Ltd., Shanghai, ChinaDepartment of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, GermanyDepartment of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBone marrow adipocytes (BMAs) represent 10% of the total fat mass of the human body and serve as an energy reservoir for the skeletal niche. They function as an endocrine organ by actively secreting fatty acids, cytokines, and adipokines. The volume of BMAs increases along with age, osteoporosis and/or obesity. With the rapid development of multi-omic analysis and the advance in in vivo imaging technology, further distinct characteristics and functions of BMAs have been revealed. There is accumulating evidence that BMAs are metabolically, biologically and functionally unique from white, brown, beige and pink adipocytes. Bone metastatic disease is an uncurable complication in cancer patients, where primary cancer cells spread from their original site into the bone marrow. Recent publications have highlighted those BMAs could also serve as a rich lipid source of fatty acids that can be utilized by the cancer cells during bone metastasis, particularly for breast, prostate, lung, ovarian and pancreatic cancer as well as melanoma. In this review, we summarize the novel progressions in BMAs metabolism, especially with multi-omic analysis and in vivo imaging technology. We also update the metabolic role of BMAs in bone metastasis, and their potential new avenues for diagnosis and therapies against metastatic cancers.https://www.frontiersin.org/articles/10.3389/fendo.2022.902033/fullbone marrow adipocyteslineage-tracingmetabolismbone metastasismulti-omic analysis |
| spellingShingle | Yixuan Li Shan Cao Shan Cao Anastasia Gaculenko Yifan Zhan Aline Bozec Xiaoxiang Chen Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis Frontiers in Endocrinology bone marrow adipocytes lineage-tracing metabolism bone metastasis multi-omic analysis |
| title | Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis |
| title_full | Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis |
| title_fullStr | Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis |
| title_full_unstemmed | Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis |
| title_short | Distinct Metabolism of Bone Marrow Adipocytes and their Role in Bone Metastasis |
| title_sort | distinct metabolism of bone marrow adipocytes and their role in bone metastasis |
| topic | bone marrow adipocytes lineage-tracing metabolism bone metastasis multi-omic analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.902033/full |
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