Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells

Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells

Myotonic dystrophy type 1 (DM1) is a dominantly inherited disorder due to a toxic gain of function of RNA transcripts containing expanded CUG repeats (CUGexp). Patients with DM1 present with multisystemic symptoms, such as muscle wasting, cognitive impairment, cataract, frontal baldness, and endocri...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Yuhei Hasuike, Hideki Mochizuki, Masayuki Nakamori
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Frontiers Media S.A. 2022-03-01
Cyfres:Frontiers in Genetics
Pynciau:
IGFBP3
PAI-1
repeat expansion
cellular senescence
reactive oxygen species
myotonic dystrophy
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fgene.2022.865811/full

Rhyngrwyd

https://www.frontiersin.org/articles/10.3389/fgene.2022.865811/full

Eitemau Tebyg