Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver
Purpose: To explore the diagnostic value of Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System version 2017 (CEUS LI-RADS v2017) in differentiating alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) from other primary malignancies (OM) of the liver. Methods: The data o...
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/12/2250 |
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| author | Peihua Wang Fang Nie Tiantian Dong Dan Yang Ting Liu Guojuan Wang |
| author_facet | Peihua Wang Fang Nie Tiantian Dong Dan Yang Ting Liu Guojuan Wang |
| author_sort | Peihua Wang |
| collection | DOAJ |
| description | Purpose: To explore the diagnostic value of Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System version 2017 (CEUS LI-RADS v2017) in differentiating alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) from other primary malignancies (OM) of the liver. Methods: The data of 99 patients with primary liver malignant tumors confirmed by surgical pathology and AFP-negative from January 2018 to January 2021 were retrospectively analyzed, and the lesions were divided into 61 cases in the AFP-negative HCC group and 38 cases in the OM group according to the pathological findings, the CEUS features of the lesions were analyzed and the lesions were classified according to the CEUS LI-RADS v2017. Comparison of CEUS features between the two groups was performed using the χ<sup>2</sup> test. The sensitivity, specificity, positive predictive value, negative predictive value, and coincidence rate of CEUS LI-RADS v2017 for the diagnosis of AFP-negative HCC and OM were calculated using pathological findings as the gold standard. Results: The differences in features of arterial phase enhancement and wash-out between the HCC and OM groups were statistically significant (<i>p</i> < 0.05). The sensitivity of diagnosing HCC by LR-5 was 62.3% and the specificity was 92.1%. The sensitivity of diagnosing OM by LR-M was 92.1% and the specificity was 83.6%. Conclusions: When AFP is negative in patients with intrahepatic focal lesions, LR-5 has high specificity but low sensitivity in the diagnosis of HCC, and LR-M has high sensitivity and specificity in the diagnosis of OM. CEUS LI-RADS is a tool to differentiate AFP-negative HCC and OM effectively. |
| first_indexed | 2024-03-10T04:19:23Z |
| format | Article |
| id | doaj.art-db5050ca845b46f8b12201799e61213e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:19:23Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-db5050ca845b46f8b12201799e61213e2023-11-23T07:53:29ZengMDPI AGDiagnostics2075-44182021-12-011112225010.3390/diagnostics11122250Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the LiverPeihua Wang0Fang Nie1Tiantian Dong2Dan Yang3Ting Liu4Guojuan Wang5Medical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaMedical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaMedical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaMedical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaMedical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaMedical Center of Ultrasound, Lanzhou University Second Hospital, Lanzhou 730030, ChinaPurpose: To explore the diagnostic value of Contrast-enhanced Ultrasound Liver Imaging Reporting and Data System version 2017 (CEUS LI-RADS v2017) in differentiating alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) from other primary malignancies (OM) of the liver. Methods: The data of 99 patients with primary liver malignant tumors confirmed by surgical pathology and AFP-negative from January 2018 to January 2021 were retrospectively analyzed, and the lesions were divided into 61 cases in the AFP-negative HCC group and 38 cases in the OM group according to the pathological findings, the CEUS features of the lesions were analyzed and the lesions were classified according to the CEUS LI-RADS v2017. Comparison of CEUS features between the two groups was performed using the χ<sup>2</sup> test. The sensitivity, specificity, positive predictive value, negative predictive value, and coincidence rate of CEUS LI-RADS v2017 for the diagnosis of AFP-negative HCC and OM were calculated using pathological findings as the gold standard. Results: The differences in features of arterial phase enhancement and wash-out between the HCC and OM groups were statistically significant (<i>p</i> < 0.05). The sensitivity of diagnosing HCC by LR-5 was 62.3% and the specificity was 92.1%. The sensitivity of diagnosing OM by LR-M was 92.1% and the specificity was 83.6%. Conclusions: When AFP is negative in patients with intrahepatic focal lesions, LR-5 has high specificity but low sensitivity in the diagnosis of HCC, and LR-M has high sensitivity and specificity in the diagnosis of OM. CEUS LI-RADS is a tool to differentiate AFP-negative HCC and OM effectively.https://www.mdpi.com/2075-4418/11/12/2250contrast-enhanced ultrasoundliver imaging reporting and data systemliver tumoralpha-fetoprotein |
| spellingShingle | Peihua Wang Fang Nie Tiantian Dong Dan Yang Ting Liu Guojuan Wang Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver Diagnostics contrast-enhanced ultrasound liver imaging reporting and data system liver tumor alpha-fetoprotein |
| title | Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver |
| title_full | Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver |
| title_fullStr | Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver |
| title_full_unstemmed | Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver |
| title_short | Diagnostic Value of CEUS LI-RADS Version 2017 in Differentiating AFP-Negative Hepatocellular Carcinoma from Other Primary Malignancies of the Liver |
| title_sort | diagnostic value of ceus li rads version 2017 in differentiating afp negative hepatocellular carcinoma from other primary malignancies of the liver |
| topic | contrast-enhanced ultrasound liver imaging reporting and data system liver tumor alpha-fetoprotein |
| url | https://www.mdpi.com/2075-4418/11/12/2250 |
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