In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?
Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/3/501 |
| _version_ | 1797540873102163968 |
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| author | Ignasi Esteban Carmen Pastor-Quiñones Lorena Usero Montserrat Plana Felipe García Lorna Leal |
| author_facet | Ignasi Esteban Carmen Pastor-Quiñones Lorena Usero Montserrat Plana Felipe García Lorna Leal |
| author_sort | Ignasi Esteban |
| collection | DOAJ |
| description | Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure. |
| first_indexed | 2024-03-10T13:07:14Z |
| format | Article |
| id | doaj.art-db512d847118429d8e145751797fc879 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T13:07:14Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-db512d847118429d8e145751797fc8792023-11-21T11:03:23ZengMDPI AGViruses1999-49152021-03-0113350110.3390/v13030501In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?Ignasi Esteban0Carmen Pastor-Quiñones1Lorena Usero2Montserrat Plana3Felipe García4Lorna Leal5Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, SpainOver 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure.https://www.mdpi.com/1999-4915/13/3/501mRNAvaccinesHIVinfectious diseases |
| spellingShingle | Ignasi Esteban Carmen Pastor-Quiñones Lorena Usero Montserrat Plana Felipe García Lorna Leal In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? Viruses mRNA vaccines HIV infectious diseases |
| title | In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? |
| title_full | In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? |
| title_fullStr | In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? |
| title_full_unstemmed | In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? |
| title_short | In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure? |
| title_sort | in the era of mrna vaccines is there any hope for hiv functional cure |
| topic | mRNA vaccines HIV infectious diseases |
| url | https://www.mdpi.com/1999-4915/13/3/501 |
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