Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy
Breast cancer (BC) is one of the most diagnosed cancers worldwide and is the second cause of cancer related death in women. The most frequent cause of BC-related deaths, like many cancers, is metastasis. However, metastasis is a complicated and poorly understood process for which there is a shortage...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/13/3276 |
| _version_ | 1797528295670022144 |
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| author | Ziqi Yu Mei Song Lotfi Chouchane Xiaojing Ma |
| author_facet | Ziqi Yu Mei Song Lotfi Chouchane Xiaojing Ma |
| author_sort | Ziqi Yu |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most diagnosed cancers worldwide and is the second cause of cancer related death in women. The most frequent cause of BC-related deaths, like many cancers, is metastasis. However, metastasis is a complicated and poorly understood process for which there is a shortage of accurate prognostic indicators and effective treatments. With the rapid and ever-evolving development and application of genomic sequencing technologies, many novel molecules were identified that play previously unappreciated and important roles in the various stages of metastasis. In this review, we summarize current advancements in the functional genomic analysis of BC metastasis and discuss about the potential prognostic and therapeutic implications from the recent genomic findings. |
| first_indexed | 2024-03-10T09:56:13Z |
| format | Article |
| id | doaj.art-db51958dfce64072979882f2510c81f9 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T09:56:13Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-db51958dfce64072979882f2510c81f92023-11-22T02:20:12ZengMDPI AGCancers2072-66942021-06-011313327610.3390/cancers13133276Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and TherapyZiqi Yu0Mei Song1Lotfi Chouchane2Xiaojing Ma3Department of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USADepartment of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USADepartment of Genetic Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha P.O. Box 24144, QatarDepartment of Microbiology and Immunology, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USABreast cancer (BC) is one of the most diagnosed cancers worldwide and is the second cause of cancer related death in women. The most frequent cause of BC-related deaths, like many cancers, is metastasis. However, metastasis is a complicated and poorly understood process for which there is a shortage of accurate prognostic indicators and effective treatments. With the rapid and ever-evolving development and application of genomic sequencing technologies, many novel molecules were identified that play previously unappreciated and important roles in the various stages of metastasis. In this review, we summarize current advancements in the functional genomic analysis of BC metastasis and discuss about the potential prognostic and therapeutic implications from the recent genomic findings.https://www.mdpi.com/2072-6694/13/13/3276breast cancer metastasisgenomic analysisdiagnosisprognosistherapy |
| spellingShingle | Ziqi Yu Mei Song Lotfi Chouchane Xiaojing Ma Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy Cancers breast cancer metastasis genomic analysis diagnosis prognosis therapy |
| title | Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy |
| title_full | Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy |
| title_fullStr | Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy |
| title_full_unstemmed | Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy |
| title_short | Functional Genomic Analysis of Breast Cancer Metastasis: Implications for Diagnosis and Therapy |
| title_sort | functional genomic analysis of breast cancer metastasis implications for diagnosis and therapy |
| topic | breast cancer metastasis genomic analysis diagnosis prognosis therapy |
| url | https://www.mdpi.com/2072-6694/13/13/3276 |
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