Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study
Abstract Background Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to the other in accordance to the locality specific risk factors for lung di...
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12890-019-0972-x |
| _version_ | 1818339474593021952 |
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| author | Deus A. Ndilanha Grace A. Shayo Ramadhan Hassan Moses Byomuganyizi Leonard E. K. Lema |
| author_facet | Deus A. Ndilanha Grace A. Shayo Ramadhan Hassan Moses Byomuganyizi Leonard E. K. Lema |
| author_sort | Deus A. Ndilanha |
| collection | DOAJ |
| description | Abstract Background Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to the other in accordance to the locality specific risk factors for lung diseases. This study aimed at describing diagnoses of all specimen of patients who underwent flexible bronchoscopy at Muhimbili National Hospital from January 2013 to November 2017. Methods A retrospective hospital-based cross sectional study was conducted among 451 patients. Data was collected from archives and included both demographic and clinical variables. Descriptive statistics were used to summarize the study findings. Results There was a 3 fold increase in the number of patients who underwent flexible bronchoscopy from 57 cases in 2013 to 180 cases in 2017. About 39% (174/451) of patients underwent lung biopsies while 64.5% (291/451) underwent bronchioalveolar lavage, bronchial washings or brush cytology, alone or in combination with biopsy. Generally, 64.4% (112/174) of all lung biopsies were malignant. Adenocarcinoma was the most common diagnosis seen in 33.9% (59/174). Of 76 cytological samples which were sent for bacterial culture and sensitivity, 11/76 (11.8%) were culture positive. A total of 6 (10.7%) out of 56 samples which were sent for GeneXpert MTB/RIF tested positive for M.tuberculosis. Conclusion Adenocarcinoma was the most common diagnosis. Bacterial and mycobacterial infections were among the most reported findings in cytological samples. Suspicious tuberculosis lesions during bronchoscopy made it possible to diagnose tuberculosis which was hard to diagnose before patients were sent for bronchoscopy. |
| first_indexed | 2024-12-13T15:27:35Z |
| format | Article |
| id | doaj.art-db51b4d05ec043c3a6f87c9d9abad5a2 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-13T15:27:35Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-db51b4d05ec043c3a6f87c9d9abad5a22022-12-21T23:40:17ZengBMCBMC Pulmonary Medicine1471-24662019-11-011911710.1186/s12890-019-0972-xDiagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional studyDeus A. Ndilanha0Grace A. Shayo1Ramadhan Hassan2Moses Byomuganyizi3Leonard E. K. Lema4Department of Internal Medicine, Muhimbili University of Health and Allied SciencesDepartment of Internal Medicine, Muhimbili University of Health and Allied SciencesDepartment of Surgery, Muhimbili University of Health and Allied SciencesDepartment of Surgery, Muhimbili University of Health and Allied SciencesDepartment of Surgery, Muhimbili University of Health and Allied SciencesAbstract Background Flexible bronchoscopy enables visualization of the respiratory airway mucosa from the oropharynx to third generation branching of the tracheobronchial tree. Bronchoscopic diagnoses vary from one locality to the other in accordance to the locality specific risk factors for lung diseases. This study aimed at describing diagnoses of all specimen of patients who underwent flexible bronchoscopy at Muhimbili National Hospital from January 2013 to November 2017. Methods A retrospective hospital-based cross sectional study was conducted among 451 patients. Data was collected from archives and included both demographic and clinical variables. Descriptive statistics were used to summarize the study findings. Results There was a 3 fold increase in the number of patients who underwent flexible bronchoscopy from 57 cases in 2013 to 180 cases in 2017. About 39% (174/451) of patients underwent lung biopsies while 64.5% (291/451) underwent bronchioalveolar lavage, bronchial washings or brush cytology, alone or in combination with biopsy. Generally, 64.4% (112/174) of all lung biopsies were malignant. Adenocarcinoma was the most common diagnosis seen in 33.9% (59/174). Of 76 cytological samples which were sent for bacterial culture and sensitivity, 11/76 (11.8%) were culture positive. A total of 6 (10.7%) out of 56 samples which were sent for GeneXpert MTB/RIF tested positive for M.tuberculosis. Conclusion Adenocarcinoma was the most common diagnosis. Bacterial and mycobacterial infections were among the most reported findings in cytological samples. Suspicious tuberculosis lesions during bronchoscopy made it possible to diagnose tuberculosis which was hard to diagnose before patients were sent for bronchoscopy.http://link.springer.com/article/10.1186/s12890-019-0972-xFlexible bronchoscopyBronchioalveolar lavageBrush cytologyTransbronchial biopsyCytologyHistology |
| spellingShingle | Deus A. Ndilanha Grace A. Shayo Ramadhan Hassan Moses Byomuganyizi Leonard E. K. Lema Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study BMC Pulmonary Medicine Flexible bronchoscopy Bronchioalveolar lavage Brush cytology Transbronchial biopsy Cytology Histology |
| title | Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study |
| title_full | Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study |
| title_fullStr | Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study |
| title_full_unstemmed | Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study |
| title_short | Diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in Dar es Salaam Tanzania: a retrospective cross-sectional study |
| title_sort | diagnoses from lung specimen collected through flexible bronchoscopy from patients in a tertiary hospital in dar es salaam tanzania a retrospective cross sectional study |
| topic | Flexible bronchoscopy Bronchioalveolar lavage Brush cytology Transbronchial biopsy Cytology Histology |
| url | http://link.springer.com/article/10.1186/s12890-019-0972-x |
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