Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report
Introduction: Unilateral vocal cord paralysis is common than bilateral palsy and is mostly idiopathic in origin. Other causes may include malignancy, secondary to neck or recurrent laryngeal nerve trauma, intubation or secondary to surgery however, taxanes induces paresis which can lead to paralysis...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Otolaryngology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468548817301868 |
| _version_ | 1828821897931915264 |
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| author | Rawish Kumar Sanjay K. Munjal Naresh K. Panda |
| author_facet | Rawish Kumar Sanjay K. Munjal Naresh K. Panda |
| author_sort | Rawish Kumar |
| collection | DOAJ |
| description | Introduction: Unilateral vocal cord paralysis is common than bilateral palsy and is mostly idiopathic in origin. Other causes may include malignancy, secondary to neck or recurrent laryngeal nerve trauma, intubation or secondary to surgery however, taxanes induces paresis which can lead to paralysis following paresis of larynx. Case summary: A female patient presented with cancer of cervix (Endometrium) and developed vocal cord paralysis after completion of five cycles of treatment with injections paclitaxel 250mg/m2 and carboplatin 450mg/m2. Patient's stroboscopic examination, electromyography (EMG) confined that one vocal cord lateralized in paramedian position. Voice analysis revealed low pitch and loudness and with breathy quality. Discussion: The vocal cord paralysis was believed to have occurred due to neurotoxic effect of carboplatin and paclitaxel, as an added complication of these drugs. Carboplatin and paclitaxel above than cumulative dose can induce bilateral or unilateral vocal cord paresis or sometimes paralysis also. The concurrent amount of dose used of carboplatin and paclitaxel might have contributed to this illness in patient. |
| first_indexed | 2024-12-12T13:03:28Z |
| format | Article |
| id | doaj.art-db522fa351274d8f87c1f41a65ff1ddf |
| institution | Directory Open Access Journal |
| issn | 2468-5488 |
| language | English |
| last_indexed | 2024-12-12T13:03:28Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Otolaryngology Case Reports |
| spelling | doaj.art-db522fa351274d8f87c1f41a65ff1ddf2022-12-22T00:23:43ZengElsevierOtolaryngology Case Reports2468-54882018-03-016C383910.1016/j.xocr.2018.01.004Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case reportRawish KumarSanjay K. MunjalNaresh K. PandaIntroduction: Unilateral vocal cord paralysis is common than bilateral palsy and is mostly idiopathic in origin. Other causes may include malignancy, secondary to neck or recurrent laryngeal nerve trauma, intubation or secondary to surgery however, taxanes induces paresis which can lead to paralysis following paresis of larynx. Case summary: A female patient presented with cancer of cervix (Endometrium) and developed vocal cord paralysis after completion of five cycles of treatment with injections paclitaxel 250mg/m2 and carboplatin 450mg/m2. Patient's stroboscopic examination, electromyography (EMG) confined that one vocal cord lateralized in paramedian position. Voice analysis revealed low pitch and loudness and with breathy quality. Discussion: The vocal cord paralysis was believed to have occurred due to neurotoxic effect of carboplatin and paclitaxel, as an added complication of these drugs. Carboplatin and paclitaxel above than cumulative dose can induce bilateral or unilateral vocal cord paresis or sometimes paralysis also. The concurrent amount of dose used of carboplatin and paclitaxel might have contributed to this illness in patient.http://www.sciencedirect.com/science/article/pii/S2468548817301868CarboplatinPaclitaxelLaryngeal palsyVoiceNeurotoxic |
| spellingShingle | Rawish Kumar Sanjay K. Munjal Naresh K. Panda Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report Otolaryngology Case Reports Carboplatin Paclitaxel Laryngeal palsy Voice Neurotoxic |
| title | Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report |
| title_full | Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report |
| title_fullStr | Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report |
| title_full_unstemmed | Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report |
| title_short | Irreversible laryngeal palsy: An induced complication of carboplatin 450mg/m2 and paclitaxel 250mg/m2 - Case report |
| title_sort | irreversible laryngeal palsy an induced complication of carboplatin 450mg m2 and paclitaxel 250mg m2 case report |
| topic | Carboplatin Paclitaxel Laryngeal palsy Voice Neurotoxic |
| url | http://www.sciencedirect.com/science/article/pii/S2468548817301868 |
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