Cell membrane-based nanomaterials for theranostics of central nervous system diseases
Abstract Central nervous system (CNS) diseases have been widely acknowledged as one of the major healthy concerns globally, which lead to serious impacts on human health. There will be about 135 million CNS diseases cases worldwide by mid-century, and CNS diseases will become the second leading caus...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-023-02004-z |
| _version_ | 1797556750382006272 |
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| author | Wenyue Li Junwei Cheng Fangfei He Peisen Zhang Ni Zhang Jian Wang Qiliang Song Yi Hou Zhihua Gan |
| author_facet | Wenyue Li Junwei Cheng Fangfei He Peisen Zhang Ni Zhang Jian Wang Qiliang Song Yi Hou Zhihua Gan |
| author_sort | Wenyue Li |
| collection | DOAJ |
| description | Abstract Central nervous system (CNS) diseases have been widely acknowledged as one of the major healthy concerns globally, which lead to serious impacts on human health. There will be about 135 million CNS diseases cases worldwide by mid-century, and CNS diseases will become the second leading cause of death after the cardiovascular disease by 2040. Most CNS diseases lack of effective diagnostic and therapeutic strategies with one of the reasons that the biological barrier extremely hampers the delivery of theranostic agents. In recent years, nanotechnology-based drug delivery is a quite promising way for CNS diseases due to excellent properties. Among them, cell membrane-based nanomaterials with natural bio-surface, high biocompatibility and biosafety, are of great significance in both the diagnosis and treatment of different CNS diseases. In this review, the state of art of the fabrication of cell membranes-based nanomaterials is introduced. The characteristics of different CNS diseases, and the application of cell membranes-based nanomaterials in the theranostics are summarized. In addition, the future prospects and limitations of cell membrane nanotechnology are anticipated. Through summarizing the state of art of the fabrication, giving examples of CNS diseases, and highlighting the applications in theranostics, the current review provides designing methods and ideas for subsequent cell membrane nanomaterials. |
| first_indexed | 2024-03-10T17:07:19Z |
| format | Article |
| id | doaj.art-db53021592224d43826232973ae39099 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-10T17:07:19Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-db53021592224d43826232973ae390992023-11-20T10:47:23ZengBMCJournal of Nanobiotechnology1477-31552023-08-0121111410.1186/s12951-023-02004-zCell membrane-based nanomaterials for theranostics of central nervous system diseasesWenyue Li0Junwei Cheng1Fangfei He2Peisen Zhang3Ni Zhang4Jian Wang5Qiliang Song6Yi Hou7Zhihua Gan8College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyDepartment of Psychiatry, West China Hospital of Sichuan UniversityDepartment of Head and Neck Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical CollegeShandong Peninsula Engineering Research Center of Comprehensive Brine Utilization, Weifang University of Science and TechnologyCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyCollege of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical TechnologyAbstract Central nervous system (CNS) diseases have been widely acknowledged as one of the major healthy concerns globally, which lead to serious impacts on human health. There will be about 135 million CNS diseases cases worldwide by mid-century, and CNS diseases will become the second leading cause of death after the cardiovascular disease by 2040. Most CNS diseases lack of effective diagnostic and therapeutic strategies with one of the reasons that the biological barrier extremely hampers the delivery of theranostic agents. In recent years, nanotechnology-based drug delivery is a quite promising way for CNS diseases due to excellent properties. Among them, cell membrane-based nanomaterials with natural bio-surface, high biocompatibility and biosafety, are of great significance in both the diagnosis and treatment of different CNS diseases. In this review, the state of art of the fabrication of cell membranes-based nanomaterials is introduced. The characteristics of different CNS diseases, and the application of cell membranes-based nanomaterials in the theranostics are summarized. In addition, the future prospects and limitations of cell membrane nanotechnology are anticipated. Through summarizing the state of art of the fabrication, giving examples of CNS diseases, and highlighting the applications in theranostics, the current review provides designing methods and ideas for subsequent cell membrane nanomaterials.https://doi.org/10.1186/s12951-023-02004-zCell membraneNanomaterialsCentral nervous system diseasesTheranostics |
| spellingShingle | Wenyue Li Junwei Cheng Fangfei He Peisen Zhang Ni Zhang Jian Wang Qiliang Song Yi Hou Zhihua Gan Cell membrane-based nanomaterials for theranostics of central nervous system diseases Journal of Nanobiotechnology Cell membrane Nanomaterials Central nervous system diseases Theranostics |
| title | Cell membrane-based nanomaterials for theranostics of central nervous system diseases |
| title_full | Cell membrane-based nanomaterials for theranostics of central nervous system diseases |
| title_fullStr | Cell membrane-based nanomaterials for theranostics of central nervous system diseases |
| title_full_unstemmed | Cell membrane-based nanomaterials for theranostics of central nervous system diseases |
| title_short | Cell membrane-based nanomaterials for theranostics of central nervous system diseases |
| title_sort | cell membrane based nanomaterials for theranostics of central nervous system diseases |
| topic | Cell membrane Nanomaterials Central nervous system diseases Theranostics |
| url | https://doi.org/10.1186/s12951-023-02004-z |
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