Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress?

Brain Endothelial Cells Release Apical and Basolateral Microparticles in Response to Inflammatory Cytokine Stimulation: Relevance to Neuroinflammatory Stress?

Microparticles (MP) are regarded both as biomarkers and mediators of many forms of pathology, including neurovascular inflammation. Here, we characterized vectorial release of apical and basolateral MPs (AMPs and BMPs) from control and TNF-α/IFN-γ treated human brain endothelial monolayers, studied...

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Bibliographic Details
Main Authors: J. Winny Yun, Mansoureh Barzegar, Christen J. Boyer, Alireza Minagar, Pierre-Olivier Couraud, Jonathan Steven Alexander
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
inflammation
neurovascular
microparticle
extracellular vesicle
brain
endothelial
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01455/full

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