Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells

Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells

Invariant natural killer T (iNKT) cells represent a unique population of CD1d-restricted T lymphocytes expressing an invariant T cell receptor encoded by Vα14-Jα18 and Vα24-Jα18 gene segments in mice and humans, respectively. Recognition of CD1d-loaded endogenous lipid antigen(s) on CD4/CD8-double p...

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Bibliographic Details
Main Authors: Zoran V. Popovic, Mariona Rabionet, Richard Jennemann, Damir Krunic, Roger Sandhoff, Hermann-Josef Gröne, Stefan Porubsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
CD1
glycosphingolipid
glucosylceramide
glucosylceramide synthase
natural killer T cell
thymus
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00848/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00848/full

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