Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

Deficiency of MGAT2 increases energy expenditure without high-fat feeding and protects genetically obese mice from excessive weight gain

Acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) is thought to be crucial for dietary fat absorption. Indeed, mice lacking the enzyme (Mogat2−/−) are resistant to obesity and other metabolic disorders induced by high-fat feeding. However, these mice absorb normal quantities of fat. To explore whe...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	David W. Nelson, Yu Gao, Nicole M. Spencer, Taylor Banh, Chi-Liang Eric Yen
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Elsevier 2011-09-01
Cyfres:	Journal of Lipid Research
Pynciau:	triacylglycerol dietary fat neutral lipid metabolism monoacylglycerol acyltransferase high fat
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S0022227520408636

Eitemau Tebyg

Catalytic properties of MGAT3, a putative triacylgycerol synthases⃞
gan: Jingsong Cao, et al.
Cyhoeddwyd: (2007-03-01)

Expression of mouse MGAT in Arabidopsis results in increased lipid accumulation in seeds
gan: Anna eEl Tahchy, et al.
Cyhoeddwyd: (2015-12-01)

Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice
gan: Yu Gao, et al.
Cyhoeddwyd: (2013-06-01)

Inhibition of MGAT2 modulates fat‐induced gut peptide release and fat intake in normal mice and ameliorates obesity and diabetes in ob/ob mice fed on a high‐fat diet
gan: Taisuke Mochida, et al.
Cyhoeddwyd: (2020-03-01)

MGAT2 deficiency ameliorates high-fat diet-induced obesity and insulin resistance by inhibiting intestinal fat absorption in mice
gan: Tsuchida Takuma, et al.
Cyhoeddwyd: (2012-06-01)

Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS[S]
gan: Joelle M. Onorato, et al.
Cyhoeddwyd: (2015-03-01)

Regular moderate aerobic exercise improves high-fat diet-induced nonalcoholic fatty liver disease via monoacylglycerol O-acyltransferase 1 pathway suppression
gan: Kyung-Wan Baek, et al.
Cyhoeddwyd: (2020-09-01)

Lipase-catalyzed glycerolysis extended to the conversion of a variety of edible oils into structural fats
gan: Reed A. Nicholson, et al.
Cyhoeddwyd: (2021-01-01)

Lipid Oxidation in Dispersive Systems with Monoacylglycerols
gan: V. Spěváčková, et al.
Cyhoeddwyd: (2009-06-01)

Phospholipase A2 relieves phosphatidylcholine inhibition of micellar cholesterol absorption and transport by human intestinal cell line Caco-21
gan: Reynold Homan, et al.
Cyhoeddwyd: (1998-06-01)

Humanized monoacylglycerol acyltransferase 2 mice develop metabolic dysfunction-associated steatohepatitis
gan: J. Jose Corbalan, et al.
Cyhoeddwyd: (2024-12-01)

GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis[S]
gan: Dandan Shan, et al.
Cyhoeddwyd: (2010-07-01)

Phosphatidylcholine deficiency upregulates enzymes of triacylglycerol metabolism in CHO cells
gan: J. Matías Caviglia, et al.
Cyhoeddwyd: (2004-08-01)

Diet Induced Obesity Alters Intestinal Cytoplasmic Lipid Droplet Morphology and Proteome in the Postprandial Response to Dietary Fat
gan: Theresa D’Aquila, et al.
Cyhoeddwyd: (2019-03-01)

slr2103, a homolog of type-2 diacylglycerol acyltransferase genes, for plastoquinone-related neutral lipid synthesis and NaCl-stress acclimatization in a cyanobacterium, Synechocystis sp. PCC 6803
gan: Mimari Kondo, et al.
Cyhoeddwyd: (2023-04-01)

Research Progress on Enzymatic Production and Application of Diacylglycerol from Livestock and Poultry Fats
gan: ZHU Chaozhi, GUO Qi, ZHAO Zexin, WANG Weifei, CUI Wenming, XU Long, ZHAO Gaiming, LI Hang
Cyhoeddwyd: (2024-02-01)

Review of the evidence for the potential impact and feasibility of substituting saturated fat in the New Zealand diet
gan: Rachel H. Foster, et al.
Cyhoeddwyd: (2013-08-01)

A Shift in Glycerolipid Metabolism Defines the Follicular Fluid of IVF Patients with Unexplained Infertility
gan: Albert Batushansky, et al.
Cyhoeddwyd: (2020-07-01)

Mise au point sur l’analyse de la régiodistribution en acides gras des triacylglycérols
gan: Turon Fabrice
Cyhoeddwyd: (2003-03-01)

A Practical Standardized Fat Challenge for the Oral Fat Tolerance Test (OFTT) in Men and Women
gan: Francine dos Santos-Macedo, et al.
Cyhoeddwyd: (2024-04-01)

The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
gan: Chi-Liang Eric Yen, et al.
Cyhoeddwyd: (2005-07-01)

A novel pathway for lipid biosynthesis: the direct acylation of glycerol
gan: Douglas P. Lee, et al.
Cyhoeddwyd: (2001-12-01)

Drosophila melanogaster as an alternative animal model in fat metabolism studies
gan: Dilan de Silva, et al.
Cyhoeddwyd: (2024-07-01)

Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of SREBP-1 expression
gan: F. Jeffrey Field, et al.
Cyhoeddwyd: (2003-06-01)

Human Milk Fat Substitute Produced by Enzymatic Interesterification of Vegetable Oil Blend
gan: Semra Turan, et al.
Cyhoeddwyd: (2007-01-01)

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice
gan: Anil K. Agarwal, et al.
Cyhoeddwyd: (2016-04-01)

Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice
gan: Talita da Silva Mendes de Farias, et al.
Cyhoeddwyd: (2019-11-01)

Lipid Alterations in Chronic Nonspecific Low Back Pain in the Chinese Population: A Metabolomic and Lipidomic Study
gan: Wen Tang, et al.
Cyhoeddwyd: (2024-11-01)

Plasma lutein concentrations are related to dietary intake, but unrelated to dietary saturated fat or cognition in young children
gan: Kelly A. Mulder, et al.
Cyhoeddwyd: (2014-01-01)

Multiple antisense oligonucleotides targeted against monoacylglycerol acyltransferase 1 (Mogat1) improve glucose metabolism independently of Mogat1
gan: Andrew J. Lutkewitte, et al.
Cyhoeddwyd: (2021-07-01)

Depot-specific effects of the PPARγ agonist rosiglitazone on adipose tissue glucose uptake and metabolism[S]
gan: William T. Festuccia, et al.
Cyhoeddwyd: (2009-06-01)

Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity
gan: John D. Douglass, et al.
Cyhoeddwyd: (2015-06-01)

Effects of age group and oil type supplementation on fat deposition in kacang goats
gan: Karami, Morteza, et al.
Cyhoeddwyd: (2009)

Lipid Metabolism in Plants
gan: Hyun Uk Kim
Cyhoeddwyd: (2020-07-01)

A phospholipid:diacylglycerol acyltransferase is involved in the regulation of phospholipids homeostasis in oleaginous Aurantiochytrium sp.
gan: Huidan Zhang, et al.
Cyhoeddwyd: (2023-09-01)

Glycerophosphate/Acylglycerophosphate Acyltransferases
gan: Atsushi Yamashita, et al.
Cyhoeddwyd: (2014-11-01)

Arabidopsis cytosolic acyl‐CoA‐binding proteins function in determining seed oil composition
gan: Ze‐Hua Guo, et al.
Cyhoeddwyd: (2019-12-01)

Impact of Phosphate Availability on Membrane Lipid Content of the Model Strains, Streptomyces lividans and Streptomyces coelicolor
gan: Clara Lejeune, et al.
Cyhoeddwyd: (2021-02-01)

Increased dietary triacylglycerol markedly enhances the ability of isolated rabbit enterocytes to secrete chylomicrons: an effect related to dietary fatty acid composition
gan: Ian J. Cartwright, et al.
Cyhoeddwyd: (1999-10-01)

Effect of some refining steps on rapeseed oil triacylglycerol structures
gan: Š. Schmidt, et al.
Cyhoeddwyd: (2004-12-01)