Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases
Abstract Background Epidemiological studies have shown a close association between osteoarthritis (OA) and cardiovascular disease (CVD), but reliable evidence needs to be provided. We performed a two‐sample Mendelian randomization (MR) study to examine the potential causal effect between OA and CVD....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Rheumatology & Autoimmunity |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rai2.12097 |
| _version_ | 1797346980555390976 |
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| author | Shengxiao Zhang Yige Feng Xinyu Yin Qinyi Su Yujia Xi Ting Cheng Heyi Zhang Yulong Xue Caihong Wang Xiaofeng Li |
| author_facet | Shengxiao Zhang Yige Feng Xinyu Yin Qinyi Su Yujia Xi Ting Cheng Heyi Zhang Yulong Xue Caihong Wang Xiaofeng Li |
| author_sort | Shengxiao Zhang |
| collection | DOAJ |
| description | Abstract Background Epidemiological studies have shown a close association between osteoarthritis (OA) and cardiovascular disease (CVD), but reliable evidence needs to be provided. We performed a two‐sample Mendelian randomization (MR) study to examine the potential causal effect between OA and CVD. Methods Exposures were self‐reported OA, knee osteoarthritis (KOA), and hip osteoarthritis (HOA). The outcomes were 12 CVDs, including heart failure, atrial fibrillation, coronary artery disease, pulmonary embolism, stroke and its subtypes, myocardial infarction, coronary heart disease, and primary hypertension. All outcomes were obtained from published genome‐wide association studies. The inverse‐variance weighted method was used as the primary MR analysis. Heterogeneity tests and sensitivity analyses were conducted to validate the accuracy of the MR results. Results Self‐reported OA increased the incidence of small vessel stroke (odds ratio [OR] = 1.25, 95% confidence interval [CI]: 1.02–1.52, p = 0.03) and primary hypertension (1.01 [1.00–1.02], p < 0.01). HOA increased the incidence of stroke (1.06 [1.01–1.11], p = 0.02) and two subtypes (cardioembolic stroke: 1.12 [1.02–1.23], p = 0.02; ischemic stroke: 1.06 [1.01–1.11], p = 0.03). Patients with KOA had an increased risk of heart failure (1.10 [1.04–1.16], p < 0.01), atrial fibrillation (1.08 [1.02–1.13], p < 0.01), small vessel stroke (1.21 [1.06–1.39], p = 0.01), and primary hypertension (1.01 [1.01–1.02], p < 0.01). Conclusions Patients with OA have an increased risk of several CVDs. The causality of this relationship may have clinical implications for improving the quality of prevention and treatment. |
| first_indexed | 2024-03-08T11:40:51Z |
| format | Article |
| id | doaj.art-db5efb4ef11c4ebe8369f233a1be1816 |
| institution | Directory Open Access Journal |
| issn | 2767-1429 |
| language | English |
| last_indexed | 2024-03-08T11:40:51Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Rheumatology & Autoimmunity |
| spelling | doaj.art-db5efb4ef11c4ebe8369f233a1be18162024-01-25T06:31:12ZengWileyRheumatology & Autoimmunity2767-14292023-12-013423023910.1002/rai2.12097Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseasesShengxiao Zhang0Yige Feng1Xinyu Yin2Qinyi Su3Yujia Xi4Ting Cheng5Heyi Zhang6Yulong Xue7Caihong Wang8Xiaofeng Li9Department of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaAcademy of Microbial Ecology Shanxi Medical University Taiyuan Shanxi ChinaAcademy of Microbial Ecology Shanxi Medical University Taiyuan Shanxi ChinaDepartment of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaDepartment of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaDepartment of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaAcademy of Microbial Ecology Shanxi Medical University Taiyuan Shanxi ChinaShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital Third Hospital of Shanxi Medical University Taiyuan Shanxi ChinaDepartment of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaDepartment of Rheumatology The Second Hospital of Shanxi Medical University Taiyuan Shanxi ChinaAbstract Background Epidemiological studies have shown a close association between osteoarthritis (OA) and cardiovascular disease (CVD), but reliable evidence needs to be provided. We performed a two‐sample Mendelian randomization (MR) study to examine the potential causal effect between OA and CVD. Methods Exposures were self‐reported OA, knee osteoarthritis (KOA), and hip osteoarthritis (HOA). The outcomes were 12 CVDs, including heart failure, atrial fibrillation, coronary artery disease, pulmonary embolism, stroke and its subtypes, myocardial infarction, coronary heart disease, and primary hypertension. All outcomes were obtained from published genome‐wide association studies. The inverse‐variance weighted method was used as the primary MR analysis. Heterogeneity tests and sensitivity analyses were conducted to validate the accuracy of the MR results. Results Self‐reported OA increased the incidence of small vessel stroke (odds ratio [OR] = 1.25, 95% confidence interval [CI]: 1.02–1.52, p = 0.03) and primary hypertension (1.01 [1.00–1.02], p < 0.01). HOA increased the incidence of stroke (1.06 [1.01–1.11], p = 0.02) and two subtypes (cardioembolic stroke: 1.12 [1.02–1.23], p = 0.02; ischemic stroke: 1.06 [1.01–1.11], p = 0.03). Patients with KOA had an increased risk of heart failure (1.10 [1.04–1.16], p < 0.01), atrial fibrillation (1.08 [1.02–1.13], p < 0.01), small vessel stroke (1.21 [1.06–1.39], p = 0.01), and primary hypertension (1.01 [1.01–1.02], p < 0.01). Conclusions Patients with OA have an increased risk of several CVDs. The causality of this relationship may have clinical implications for improving the quality of prevention and treatment.https://doi.org/10.1002/rai2.12097cardiovascular diseasesMendelian randomization analysisosteoarthritis |
| spellingShingle | Shengxiao Zhang Yige Feng Xinyu Yin Qinyi Su Yujia Xi Ting Cheng Heyi Zhang Yulong Xue Caihong Wang Xiaofeng Li Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases Rheumatology & Autoimmunity cardiovascular diseases Mendelian randomization analysis osteoarthritis |
| title | Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| title_full | Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| title_fullStr | Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| title_full_unstemmed | Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| title_short | Genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| title_sort | genetic evidence suggesting the predicted causality between osteoarthritis and cardiovascular diseases |
| topic | cardiovascular diseases Mendelian randomization analysis osteoarthritis |
| url | https://doi.org/10.1002/rai2.12097 |
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