Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review
Abstract Background Occult hepatitis B infection (OBI) is a transfusion‐transmitted infection. Although, screening the hepatitis B virus among blood donors can play an important role in increasing the health of blood products, OBI screening in blood transfusion centers is still a challenge. This rev...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1466 |
| _version_ | 1797542976487948288 |
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| author | Mohammad Hossein Ahmadi Zohreh Sharifi Ali Ghasemi Sadegh Abbasian |
| author_facet | Mohammad Hossein Ahmadi Zohreh Sharifi Ali Ghasemi Sadegh Abbasian |
| author_sort | Mohammad Hossein Ahmadi |
| collection | DOAJ |
| description | Abstract Background Occult hepatitis B infection (OBI) is a transfusion‐transmitted infection. Although, screening the hepatitis B virus among blood donors can play an important role in increasing the health of blood products, OBI screening in blood transfusion centers is still a challenge. This review study aimed to appraise the challenges of OBI screening and its associated do's and don'ts in blood transfusion centers. Methods In this review study, a search was conducted on the electronic databases of PubMed, Web of Science, Scopus, Ovid, Irandoc, and Magiran from January 1996 to December 2020. Also, cross‐sectional studies that determined the prevalence of OBI or anti‐HBc were included in the study. In addition, studies with incomplete data on the prevalence of OBI were excluded. Results The prevalence of OBI varies among Iranian blood donors. The rates reported by blood transfusion centers of Mashhad, Ahvaz, and Tehran were 0%, and Isfahan, Shiraz, and Kerman were 0.9%, 0.08%, and 2.36%, respectively. In areas with high prevalence of hepatitis B virus, OBI screening only by anti‐HBc test led to the exemption of blood donors from donating blood. Avoiding OBI screening also effected the risk of virus transmission to blood recipients. Plasma products had a higher risk (85%) of virus transmission. Conclusions Determining an appropriate screening strategy based on prevalence status, the cost‐effectiveness of screening tests, and the policies of each blood transfusion center is essential. |
| first_indexed | 2024-03-10T13:38:10Z |
| format | Article |
| id | doaj.art-db5fd2da270e4600a55b41ec0d51d97e |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-10T13:38:10Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-db5fd2da270e4600a55b41ec0d51d97e2023-11-21T06:37:12ZengWileyHealth Science Reports2398-88352023-08-0168n/an/a10.1002/hsr2.1466Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative reviewMohammad Hossein Ahmadi0Zohreh Sharifi1Ali Ghasemi2Sadegh Abbasian3Department of Laboratory Science, School of Paramedical and Rehabilitation Sciences Mashhad University of Medical Sciences Mashhad IranBlood Transfusion Research Center High Institute for Research and Education in Transfusion Medicine Tehran IranDepartemant of Biochemistry and Hematology Faculty of Medicine Semnan University of Medical Science Semnan IranStudent Research Committee Ilam University of Medical Sciences Ilam IranAbstract Background Occult hepatitis B infection (OBI) is a transfusion‐transmitted infection. Although, screening the hepatitis B virus among blood donors can play an important role in increasing the health of blood products, OBI screening in blood transfusion centers is still a challenge. This review study aimed to appraise the challenges of OBI screening and its associated do's and don'ts in blood transfusion centers. Methods In this review study, a search was conducted on the electronic databases of PubMed, Web of Science, Scopus, Ovid, Irandoc, and Magiran from January 1996 to December 2020. Also, cross‐sectional studies that determined the prevalence of OBI or anti‐HBc were included in the study. In addition, studies with incomplete data on the prevalence of OBI were excluded. Results The prevalence of OBI varies among Iranian blood donors. The rates reported by blood transfusion centers of Mashhad, Ahvaz, and Tehran were 0%, and Isfahan, Shiraz, and Kerman were 0.9%, 0.08%, and 2.36%, respectively. In areas with high prevalence of hepatitis B virus, OBI screening only by anti‐HBc test led to the exemption of blood donors from donating blood. Avoiding OBI screening also effected the risk of virus transmission to blood recipients. Plasma products had a higher risk (85%) of virus transmission. Conclusions Determining an appropriate screening strategy based on prevalence status, the cost‐effectiveness of screening tests, and the policies of each blood transfusion center is essential.https://doi.org/10.1002/hsr2.1466blood donorsblood transfusionhepatitisinfectionprevalence |
| spellingShingle | Mohammad Hossein Ahmadi Zohreh Sharifi Ali Ghasemi Sadegh Abbasian Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review Health Science Reports blood donors blood transfusion hepatitis infection prevalence |
| title | Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review |
| title_full | Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review |
| title_fullStr | Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review |
| title_full_unstemmed | Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review |
| title_short | Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review |
| title_sort | occult hepatitis b in iranian blood donors an overview of the challenges a narrative review |
| topic | blood donors blood transfusion hepatitis infection prevalence |
| url | https://doi.org/10.1002/hsr2.1466 |
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