Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma
Summary: The carcinogenesis and progression of hepatocellular carcinoma (HCC) are closely related to viral infection and intestinal bacteria. However, little is known about bacteria within the HCC tumor microenvironment. Here, we showed that intratumoral Mycoplasma hyorhinis (M. hyorhinis) promoted...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015759 |
| _version_ | 1797391816995110912 |
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| author | Kailiang Qiao Jingxia Han Haohao Zhang Yinan Li Xiaohui Hou Yan Jia Yujie Sun Huan Wang Zheng Xu Haoyang Liu Heng Zhang Huijuan Liu Wei Zhang Tao Sun |
| author_facet | Kailiang Qiao Jingxia Han Haohao Zhang Yinan Li Xiaohui Hou Yan Jia Yujie Sun Huan Wang Zheng Xu Haoyang Liu Heng Zhang Huijuan Liu Wei Zhang Tao Sun |
| author_sort | Kailiang Qiao |
| collection | DOAJ |
| description | Summary: The carcinogenesis and progression of hepatocellular carcinoma (HCC) are closely related to viral infection and intestinal bacteria. However, little is known about bacteria within the HCC tumor microenvironment. Here, we showed that intratumoral Mycoplasma hyorhinis (M. hyorhinis) promoted the initiation and progression of HCC by enhancing nuclear ploidy. We quantified M. hyorhinis in clinical tissue specimens of HCC and observed that patients with high M. hyorhinis load had poor prognosis. We found that gastrointestinal M. hyorhinis can retrogradely infect the liver through the oral-duodenal-hepatopancreatic ampulla route. We further found that the increases in mononuclear polyploidy and cancer stemness resulted from mitochondrial fission caused by intracellular M. hyorhinis. Mechanistically, M. hyorhinis infection promoted the decay of mitochondrial fusion protein (MFN) 1 mRNA in an m6A-dependent manner. Our findings indicated that M. hyorhinis infection promoted pathological polyploidization and suggested that Mycoplasma clearance with antibiotics or regulating mitochondrial dynamics might have the potential for HCC therapy. |
| first_indexed | 2024-03-08T23:38:11Z |
| format | Article |
| id | doaj.art-db62175685ad40ee9c451b5699585ce5 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T23:38:11Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-db62175685ad40ee9c451b5699585ce52023-12-14T05:22:44ZengElsevierCell Reports2211-12472023-12-014212113563Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinomaKailiang Qiao0Jingxia Han1Haohao Zhang2Yinan Li3Xiaohui Hou4Yan Jia5Yujie Sun6Huan Wang7Zheng Xu8Haoyang Liu9Heng Zhang10Huijuan Liu11Wei Zhang12Tao Sun13State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China; Corresponding authorDepartment of Hepatobiliary Cancer, Research Center for Prevention and Treatment of Liver Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300040, China; Corresponding authorState Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300350, China; Corresponding authorSummary: The carcinogenesis and progression of hepatocellular carcinoma (HCC) are closely related to viral infection and intestinal bacteria. However, little is known about bacteria within the HCC tumor microenvironment. Here, we showed that intratumoral Mycoplasma hyorhinis (M. hyorhinis) promoted the initiation and progression of HCC by enhancing nuclear ploidy. We quantified M. hyorhinis in clinical tissue specimens of HCC and observed that patients with high M. hyorhinis load had poor prognosis. We found that gastrointestinal M. hyorhinis can retrogradely infect the liver through the oral-duodenal-hepatopancreatic ampulla route. We further found that the increases in mononuclear polyploidy and cancer stemness resulted from mitochondrial fission caused by intracellular M. hyorhinis. Mechanistically, M. hyorhinis infection promoted the decay of mitochondrial fusion protein (MFN) 1 mRNA in an m6A-dependent manner. Our findings indicated that M. hyorhinis infection promoted pathological polyploidization and suggested that Mycoplasma clearance with antibiotics or regulating mitochondrial dynamics might have the potential for HCC therapy.http://www.sciencedirect.com/science/article/pii/S2211124723015759CP: CancerCP: Microbiology |
| spellingShingle | Kailiang Qiao Jingxia Han Haohao Zhang Yinan Li Xiaohui Hou Yan Jia Yujie Sun Huan Wang Zheng Xu Haoyang Liu Heng Zhang Huijuan Liu Wei Zhang Tao Sun Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma Cell Reports CP: Cancer CP: Microbiology |
| title | Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| title_full | Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| title_fullStr | Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| title_full_unstemmed | Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| title_short | Intratumor Mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| title_sort | intratumor mycoplasma promotes the initiation and progression of hepatocellular carcinoma |
| topic | CP: Cancer CP: Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723015759 |
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