Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade
Pulmonary arterial hypertension (PAH) is a rare but well-known cardiovascular condition potentially associated with human immunodeficiency virus (HIV) infection and is currently recognized to be one of the most ominous noninfectious HIV complications. Although there is no clear evidence supporting t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-02-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753465808101549 |
| _version_ | 1818351587681107968 |
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| author | Valerio Zacà Marco Metra Rossella Danesi Carlo Lombardi Giulia Verzura Livio Dei Cas |
| author_facet | Valerio Zacà Marco Metra Rossella Danesi Carlo Lombardi Giulia Verzura Livio Dei Cas |
| author_sort | Valerio Zacà |
| collection | DOAJ |
| description | Pulmonary arterial hypertension (PAH) is a rare but well-known cardiovascular condition potentially associated with human immunodeficiency virus (HIV) infection and is currently recognized to be one of the most ominous noninfectious HIV complications. Although there is no clear evidence supporting the use of any medication for the treatment of HIV-related PAH, many of the currently available agents have been shown to exert some clinical benefits HIV-PAH patients. To date, no data are available regarding the potential effects of sitaxsentan, a selective endothelin type-A receptor antagonist, in this peculiar patient population. We report the case of a successful switch to sitaxsentan in a HIV-infected patient with PAH initially receiving bosentan who developed a late treatment-related side-effect. |
| first_indexed | 2024-12-13T18:40:07Z |
| format | Article |
| id | doaj.art-db6259b7b4404b389b229eb02cb6c6ae |
| institution | Directory Open Access Journal |
| issn | 1753-4658 |
| language | English |
| last_indexed | 2024-12-13T18:40:07Z |
| publishDate | 2009-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-db6259b7b4404b389b229eb02cb6c6ae2022-12-21T23:35:15ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46582009-02-01310.1177/1753465808101549Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockadeValerio ZacàMarco MetraRossella DanesiCarlo LombardiGiulia VerzuraLivio Dei CasPulmonary arterial hypertension (PAH) is a rare but well-known cardiovascular condition potentially associated with human immunodeficiency virus (HIV) infection and is currently recognized to be one of the most ominous noninfectious HIV complications. Although there is no clear evidence supporting the use of any medication for the treatment of HIV-related PAH, many of the currently available agents have been shown to exert some clinical benefits HIV-PAH patients. To date, no data are available regarding the potential effects of sitaxsentan, a selective endothelin type-A receptor antagonist, in this peculiar patient population. We report the case of a successful switch to sitaxsentan in a HIV-infected patient with PAH initially receiving bosentan who developed a late treatment-related side-effect.https://doi.org/10.1177/1753465808101549 |
| spellingShingle | Valerio Zacà Marco Metra Rossella Danesi Carlo Lombardi Giulia Verzura Livio Dei Cas Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade Therapeutic Advances in Respiratory Disease |
| title | Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| title_full | Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| title_fullStr | Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| title_full_unstemmed | Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| title_short | Successful switch to sitaxsentan in a patient with HIV-related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| title_sort | successful switch to sitaxsentan in a patient with hiv related pulmonary arterial hypertension and late intolerance to nonselective endothelin receptor blockade |
| url | https://doi.org/10.1177/1753465808101549 |
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