Proton Pump Inhibitor and Tacrolimus Uses are Associated With Hypomagnesemia in Connective Tissue Disease: a Potential Link With Renal Dysfunction and Recurrent Infection

Proton Pump Inhibitor and Tacrolimus Uses are Associated With Hypomagnesemia in Connective Tissue Disease: a Potential Link With Renal Dysfunction and Recurrent Infection

Background: Low levels of serum magnesium perturb renal tubular cell function and lymphocytes, resulting in renal deterioration and an imbalance in mononuclear cells. This study investigated the mechanism and influence of hypomagnesemia in patients with connective tissue disease.Methods: We retrospe...

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Bibliographic Details
Main Authors:	Hironari Hanaoka, Jun Kikuchi, Yuko Kaneko, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba, Tsutomu Takeuchi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Series:	Frontiers in Pharmacology
Subjects:	proton pump inhibitor tacrolimus magnesium hypomagnesemia connective tissue disease hypomagnesemia in rheumatology
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.616719/full

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