Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review
Background: Recently, the role of nutraceutical compounds in the prevention of human diseases has been rapidly increasing. Here, we aim to evaluate the beneficial effect of dietary supplementation with seven active principles, i.e., lycopene, sulforaphane, silymarin, glutathione, escin, tryptophan,...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Online Access: | https://www.mdpi.com/2673-4397/3/3/22 |
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| author | Francesco Sebastiani Carlo D’Alterio Cristina Vocca Luca Gallelli Fabrizio Palumbo Tommaso Cai Alessandro Palmieri |
| author_facet | Francesco Sebastiani Carlo D’Alterio Cristina Vocca Luca Gallelli Fabrizio Palumbo Tommaso Cai Alessandro Palmieri |
| author_sort | Francesco Sebastiani |
| collection | DOAJ |
| description | Background: Recently, the role of nutraceutical compounds in the prevention of human diseases has been rapidly increasing. Here, we aim to evaluate the beneficial effect of dietary supplementation with seven active principles, i.e., lycopene, sulforaphane, silymarin, glutathione, escin, tryptophan, and green tea catechins, on human health. Methods: An extensive search of PubMed and Medline database was performed with the following keywords: “silymarin”, “sulforaphane”, “lycopene”, “green tea catechins”, “tryptophan”, “glutathione” and “escin” accompanied by the keywords “supplement”, “supplementation”, and “nutraceutics”. All preclinical and clinical trials were considered for this review. Results: One hundred and eighteen full-text articles were eligible for inclusion in this review. The papers examined presented considerable variability due to the wide heterogeneity of dosages administered, population involved, and outcomes pursued. Conclusion: Nutritional supplementation with lycopene, sulforaphane, silymarin, glutathione, escin, tryptophan, and green tea catechins appears to exert a wide range of benefits on human health, ranging from mood and cognition to cardiovascular health, fertility, metabolism, antioxidant, and anti-inflammatory capabilities, as well as potential anticancer effects. Further studies are required to better define the potential synergic effect, optimal dosage, mechanism of action, and tolerability profiles of these substances. |
| first_indexed | 2024-03-10T21:52:59Z |
| format | Article |
| id | doaj.art-db63fac2f2c547c5a43372d83fd9210e |
| institution | Directory Open Access Journal |
| issn | 2673-4397 |
| language | English |
| last_indexed | 2024-03-10T21:52:59Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Uro |
| spelling | doaj.art-db63fac2f2c547c5a43372d83fd9210e2023-11-19T13:18:19ZengMDPI AGUro2673-43972023-08-013320822810.3390/uro3030022Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative ReviewFrancesco Sebastiani0Carlo D’Alterio1Cristina Vocca2Luca Gallelli3Fabrizio Palumbo4Tommaso Cai5Alessandro Palmieri6Department of Urology, Di Venere Hospital, 70131 Bari, ItalyDepartment of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples, 80138 Naples, ItalyClinical Pharmacology and Pharmacovigilance Unit, Department of Health Science, “Magna Græcia” University of Catanzaro, Dulbecco Hospital, 88100 Catanzaro, ItalyDepartment of Health Science, School of Medicine, University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Urology, Di Venere Hospital, 70131 Bari, ItalyDepartment of Urology, Santa Chiara Regional Hospital, 38123 Trento, ItalyDepartment of Urology, University of Naples, 80013 Naples, ItalyBackground: Recently, the role of nutraceutical compounds in the prevention of human diseases has been rapidly increasing. Here, we aim to evaluate the beneficial effect of dietary supplementation with seven active principles, i.e., lycopene, sulforaphane, silymarin, glutathione, escin, tryptophan, and green tea catechins, on human health. Methods: An extensive search of PubMed and Medline database was performed with the following keywords: “silymarin”, “sulforaphane”, “lycopene”, “green tea catechins”, “tryptophan”, “glutathione” and “escin” accompanied by the keywords “supplement”, “supplementation”, and “nutraceutics”. All preclinical and clinical trials were considered for this review. Results: One hundred and eighteen full-text articles were eligible for inclusion in this review. The papers examined presented considerable variability due to the wide heterogeneity of dosages administered, population involved, and outcomes pursued. Conclusion: Nutritional supplementation with lycopene, sulforaphane, silymarin, glutathione, escin, tryptophan, and green tea catechins appears to exert a wide range of benefits on human health, ranging from mood and cognition to cardiovascular health, fertility, metabolism, antioxidant, and anti-inflammatory capabilities, as well as potential anticancer effects. Further studies are required to better define the potential synergic effect, optimal dosage, mechanism of action, and tolerability profiles of these substances.https://www.mdpi.com/2673-4397/3/3/22sulphoraphanesilymarinlycopeneglutathioneescintryptophan |
| spellingShingle | Francesco Sebastiani Carlo D’Alterio Cristina Vocca Luca Gallelli Fabrizio Palumbo Tommaso Cai Alessandro Palmieri Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review Uro sulphoraphane silymarin lycopene glutathione escin tryptophan |
| title | Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review |
| title_full | Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review |
| title_fullStr | Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review |
| title_full_unstemmed | Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review |
| title_short | Effectiveness of Silymarin, Sulforaphane, Lycopene, Green Tea, Tryptophan, Glutathione, and Escin on Human Health: A Narrative Review |
| title_sort | effectiveness of silymarin sulforaphane lycopene green tea tryptophan glutathione and escin on human health a narrative review |
| topic | sulphoraphane silymarin lycopene glutathione escin tryptophan |
| url | https://www.mdpi.com/2673-4397/3/3/22 |
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