Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes
Cognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impai...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.880027/full |
| _version_ | 1811284025731448832 |
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| author | Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Hongjun Tian Jiayue Chen Qianchen Li Lei Yang Qiuyu Zhang Guangdong Chen Langlang Cheng Chunhua Zhou Xueqin Song |
| author_facet | Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Hongjun Tian Jiayue Chen Qianchen Li Lei Yang Qiuyu Zhang Guangdong Chen Langlang Cheng Chunhua Zhou Xueqin Song |
| author_sort | Chuanjun Zhuo |
| collection | DOAJ |
| description | Cognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impairments in MPD patients have been examined mostly in isolated circuits rather than in the whole brain. In the present study, genetic, neuroimaging, and psychometric approaches were combined to investigate the relationship among genetic factors, alterations throughout the brain, and cognitive impairments in a large cohort of patients diagnosed with SCZ, with a reference healthy control (HC) group. Single nucleotide polymorphisms (SNPs) in SCZ-risk genes were found to be strongly related to cognitive impairments as well as to gray matter volume (GMV) and functional connectivity (FC) alterations in the SCZ group. Annotating 136 high-ranking SNPs revealed 65 affected genes (including PPP1R16B, GBBR2, PDE4B, CANCNA1C, SLC12AB, SATB2, MAG12, and SATB2). Only one, a PDE4B SNP (rs1006737), correlated with GMV (r = 0:19 p = 0.015) and FC (r = 0.21, p = 0.0074) in SCZ patients. GMV and FC alterations correlated with one another broadly across brain regions. Moreover, the present data demonstrate three-way SNP-FC-GMV associations in patients with SCZ, thus providing clues regarding potential genetic bases of cognition impairments in SCZ. SNP-FC-GMV relationships correlated with visual learning and reasoning dimensions of cognition. These data provide evidence that SCZ-related cognitive impairments may reflect genetically underlain whole-brain structural and functional alterations. |
| first_indexed | 2024-04-13T02:22:29Z |
| format | Article |
| id | doaj.art-db6420054b0141278661f3cc3372c391 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T02:22:29Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-db6420054b0141278661f3cc3372c3912022-12-22T03:06:55ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.880027880027Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changesChuanjun Zhuo0Chuanjun Zhuo1Chuanjun Zhuo2Chuanjun Zhuo3Chuanjun Zhuo4Hongjun Tian5Jiayue Chen6Qianchen Li7Lei Yang8Qiuyu Zhang9Guangdong Chen10Langlang Cheng11Chunhua Zhou12Xueqin Song13Key Laboratory of Real Time Tracing of Brian Circuits in Psychiatry and Neurology (RTBNP_Lab), Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin Fourth Center Hospital, Tianjin, ChinaDigital Analysis Center of Psychiatry, Tianjin Fourth Center Hospital, Tianjin, ChinaDepartment of Psychiatry and Neurology Imaging-Genetics and Comorbidity Laboratory (PNGC_Lab) of Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDeep Learning Center of MRI and Genetics, Wenzhou Seventh People’s Hospital, Wenzhou, ChinaDepartment of Psychiatry, Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin Fourth Center Hospital, Tianjin, ChinaDepartment of Psychiatry, Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin Fourth Center Hospital, Tianjin, ChinaDepartment of Pharmacology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin Fourth Center Hospital, Tianjin, ChinaDepartment of Psychiatry, Nankai University Affiliated Tianjin Fourth Center Hospital, Tianjin Fourth Center Hospital, Tianjin, ChinaDepartment of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, ChinaDepartment of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou, ChinaDepartment of Pharmacology, The First Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaCognitive impairment is highly prevalent in patients with major psychiatric disorders (MPDs), including schizophrenia (SCZ), bipolar disorder, major depressive disorder, in whom it can be highly disruptive to community functioning and worsen prognosis. Previously, genetic factors and cognitive impairments in MPD patients have been examined mostly in isolated circuits rather than in the whole brain. In the present study, genetic, neuroimaging, and psychometric approaches were combined to investigate the relationship among genetic factors, alterations throughout the brain, and cognitive impairments in a large cohort of patients diagnosed with SCZ, with a reference healthy control (HC) group. Single nucleotide polymorphisms (SNPs) in SCZ-risk genes were found to be strongly related to cognitive impairments as well as to gray matter volume (GMV) and functional connectivity (FC) alterations in the SCZ group. Annotating 136 high-ranking SNPs revealed 65 affected genes (including PPP1R16B, GBBR2, PDE4B, CANCNA1C, SLC12AB, SATB2, MAG12, and SATB2). Only one, a PDE4B SNP (rs1006737), correlated with GMV (r = 0:19 p = 0.015) and FC (r = 0.21, p = 0.0074) in SCZ patients. GMV and FC alterations correlated with one another broadly across brain regions. Moreover, the present data demonstrate three-way SNP-FC-GMV associations in patients with SCZ, thus providing clues regarding potential genetic bases of cognition impairments in SCZ. SNP-FC-GMV relationships correlated with visual learning and reasoning dimensions of cognition. These data provide evidence that SCZ-related cognitive impairments may reflect genetically underlain whole-brain structural and functional alterations.https://www.frontiersin.org/articles/10.3389/fgene.2022.880027/fullschizophreniaSNPcognitive impairmentGMVFC |
| spellingShingle | Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Chuanjun Zhuo Hongjun Tian Jiayue Chen Qianchen Li Lei Yang Qiuyu Zhang Guangdong Chen Langlang Cheng Chunhua Zhou Xueqin Song Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes Frontiers in Genetics schizophrenia SNP cognitive impairment GMV FC |
| title | Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes |
| title_full | Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes |
| title_fullStr | Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes |
| title_full_unstemmed | Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes |
| title_short | Associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia-related structural and functional brain changes |
| title_sort | associations of cognitive impairment in patients with schizophrenia with genetic features and with schizophrenia related structural and functional brain changes |
| topic | schizophrenia SNP cognitive impairment GMV FC |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.880027/full |
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