Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

Abstract The intestinal epithelial receptor Guanylyl Cyclase C (GUCY2C) is a tumor-associated cell surface antigen expressed across gastrointestinal malignancies that can serve as an efficacious target for colorectal cancer immunotherapy. Here, we describe a yeast surface-display approach combined w...

Bibliografski detalji
Glavni autori:	Pragya Rampuria, Lidia Mosyak, Adam R. Root, Kristine Svenson, Michael J. Agostino, Edward R. LaVallie
Format:	Članak
Jezik:	English
Izdano:	Nature Portfolio 2023-08-01
Serija:	Scientific Reports
Online pristup:	https://doi.org/10.1038/s41598-023-40467-0

Slični predmeti

Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
od: Adam R. Root, i dr.
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Intestinal neuropod cell GUCY2C regulates visceral pain
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CD8α Structural Domains Enhance GUCY2C CAR-T Cell Efficacy
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GUCY2C signaling limits dopaminergic neuron vulnerability to toxic insults
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308 GUCY2C-directed CAR-T cell therapy for upper GI cancers
od: Robert Carlson, i dr.
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Overexpression of GUCY1A2 Correlates With Poor Prognosis in Gastric Cancer Patients
od: Xin Li, i dr.
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The symbolic meaning of ruwatan bumi for youth as successors of tradition in Guci, Tegal
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The Value of Creative Character of Guci Dance Through The Extracurricular Art of Dance
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Novel GUCY2D Gene Mutations in Japanese Male Twins with Leber Congenital Amaurosis
od: Katsuhiro Hosono, i dr.
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Long term follow-up of a family with GUCY2D dominant cone dystrophy
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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells
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GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
od: Jieru Egeria Lin, i dr.
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739 Development of patient-derived models of esophageal cancer for GUCY2C-directed immunotherapeutic testing
od: Robert Carlson, i dr.
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Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts
od: Valeria Rudman-Melnick, i dr.
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The natural history of Leber congenital amaurosis and cone–rod dystrophy associated with variants in the GUCY2D gene
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Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations
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347 Functional characterization of GUCY2C-TAC T cells for the treatment of colorectal cancer using preclinical models
od: Tania Benatar, i dr.
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The pathogenicity of novel GUCY2D mutations in Leber congenital amaurosis 1 assessed by HPLC-MS/MS.
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A GUCY2D variant associated cone-rod dystrophy with electronegative ERG: A case report and review
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Gucy2d selectively marks inhibitory dynorphin neurons in the spinal dorsal horn but is dispensable for pain and itch sensitivity
od: Elizabeth K. Serafin, i dr.
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A mouse model of cone photoreceptor function loss (cpfl9) with degeneration due to a mutation in Gucy2e
od: Anna S. E. N. Naggert, i dr.
Izdano: (2023-01-01)

Preclinical studies in support of phase I/II clinical trials to treat GUCY2D-associated Leber congenital amaurosis
od: Sanford L. Boye, i dr.
Izdano: (2023-03-01)

Pathogenic variants of AIPL1, MERTK, GUCY2D, and FOXE3 in Pakistani families with clinically heterogeneous eye diseases.
od: Muhammad Rashid, i dr.
Izdano: (2020-01-01)

Split tolerance permits safe Ad5-GUCY2C-PADRE vaccine-induced T-cell responses in colon cancer patients
od: Adam E. Snook, i dr.
Izdano: (2019-04-01)

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od: Ihsan Ihsan
Izdano: (2017-10-01)

<i>SELL</i> and <i>GUCY1A1</i> Gene Polymorphisms in Patients with Unstable Angina
od: Damian Malinowski, i dr.
Izdano: (2022-10-01)

RNF213 and GUCY1A3 in Moyamoya Disease: Key Regulators of Metabolism, Inflammation, and Vascular Stability
od: Yohei Mineharu, i dr.
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Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca2+-Dependent Cyclic GMP Synthesis
od: Hanna Wimberg, i dr.
Izdano: (2018-09-01)

Phosphodiesterase inhibition and Gucy2C activation enhance tyrosine hydroxylase Ser40 phosphorylation and improve 6-hydroxydopamine-induced motor deficits
od: Erik H. Douma, i dr.
Izdano: (2024-10-01)

Autosomal dominant cone-rod retinal dystrophy (CORD6) from heterozygous mutation of GUCY2D, which encodes retinal guanylate cyclase.
od: Gregory-Evans, K, i dr.
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Dampak kegiatan pariwisata terhadap lingkungan sosial budaya masyarakat di sekitar objek wisata guci kabupaten Tegal
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KAJIAN SEMIOTIK PADA TRADISI LEMPAR NASI SAAT HUJAN DI DESA GUCI KECAMATAN KARANGGENENG KABUPATEN LAMONGAN
od: Haerussaleh Haerussaleh, i dr.
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Exome sequencing identifies a novel GUCY2D mutation in an Iranian family with Leber congenital amaurosis-1: a case report
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Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity
od: Tingting Zhan, i dr.
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Functional polymorphisms of NOS3 and GUCY1A3 affect both nitric oxide formation and association with hypertensive disorders of pregnancy
od: Daniela A. Pereira, i dr.
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od: Fei Wang, i dr.
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CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells
od: K. Qi, i dr.
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Polymorphisms of the <i>HRG</i>, <i>FETUB</i>, and <i>GUCY1A1</i> genes and their association with litter size in sheep
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