Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3
Abstract The intestinal epithelial receptor Guanylyl Cyclase C (GUCY2C) is a tumor-associated cell surface antigen expressed across gastrointestinal malignancies that can serve as an efficacious target for colorectal cancer immunotherapy. Here, we describe a yeast surface-display approach combined w...
Main Authors: | Pragya Rampuria, Lidia Mosyak, Adam R. Root, Kristine Svenson, Michael J. Agostino, Edward R. LaVallie |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-08-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-40467-0 |
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