Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
Abstract Background Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods The study includes 213 ICU patients wit...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-017-2606-3 |
| _version_ | 1818958505470590976 |
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| author | Sonja Hamed Michael Behnes Dominic Pauly Dominic Lepiorz Max Barre Tobias Becher Siegfried Lang Ibrahim Akin Martin Borggrefe Thomas Bertsch Ursula Hoffmann |
| author_facet | Sonja Hamed Michael Behnes Dominic Pauly Dominic Lepiorz Max Barre Tobias Becher Siegfried Lang Ibrahim Akin Martin Borggrefe Thomas Bertsch Ursula Hoffmann |
| author_sort | Sonja Hamed |
| collection | DOAJ |
| description | Abstract Background Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. Results PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). Conclusion PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. Trial registration NCT01535534 . Registered 14.02.2012 |
| first_indexed | 2024-12-20T11:26:49Z |
| format | Article |
| id | doaj.art-db67094fc6b2432eb0e1b45d42f6f549 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-20T11:26:49Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-db67094fc6b2432eb0e1b45d42f6f5492022-12-21T19:42:21ZengBMCBMC Infectious Diseases1471-23342017-08-0117111010.1186/s12879-017-2606-3Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitionsSonja Hamed0Michael Behnes1Dominic Pauly2Dominic Lepiorz3Max Barre4Tobias Becher5Siegfried Lang6Ibrahim Akin7Martin Borggrefe8Thomas Bertsch9Ursula Hoffmann10First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergInstitute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg, Paracelsus Medical UniversityFirst Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of HeidelbergAbstract Background Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). Methods The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. Results PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). Conclusion PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. Trial registration NCT01535534 . Registered 14.02.2012http://link.springer.com/article/10.1186/s12879-017-2606-3SepsisSeptic shockPentraxin-3ICUBiomarkersSepsis-3 |
| spellingShingle | Sonja Hamed Michael Behnes Dominic Pauly Dominic Lepiorz Max Barre Tobias Becher Siegfried Lang Ibrahim Akin Martin Borggrefe Thomas Bertsch Ursula Hoffmann Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions BMC Infectious Diseases Sepsis Septic shock Pentraxin-3 ICU Biomarkers Sepsis-3 |
| title | Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions |
| title_full | Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions |
| title_fullStr | Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions |
| title_full_unstemmed | Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions |
| title_short | Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions |
| title_sort | diagnostic value of pentraxin 3 in patients with sepsis and septic shock in accordance with latest sepsis 3 definitions |
| topic | Sepsis Septic shock Pentraxin-3 ICU Biomarkers Sepsis-3 |
| url | http://link.springer.com/article/10.1186/s12879-017-2606-3 |
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