A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women
The widespread use of anti-D immunoglobulin has resulted in a relative increase in the importance of non-D alloimmunization as a cause of hemolytic disease of the fetus and newborn (HDFN). Non-D alloantibodies that are capable of causing severe HDFN include anti-K, anti-E, and anti-c. Anti-c is clin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=121;epage=123;aulast= |
| _version_ | 1811343840297091072 |
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| author | Bharat Singh Rajendra Chaudhary Preeti Elhence Jyoti Kala Bharati Anubha Srivastava |
| author_facet | Bharat Singh Rajendra Chaudhary Preeti Elhence Jyoti Kala Bharati Anubha Srivastava |
| author_sort | Bharat Singh |
| collection | DOAJ |
| description | The widespread use of anti-D immunoglobulin has resulted in a relative increase in the importance of non-D alloimmunization as a cause of hemolytic disease of the fetus and newborn (HDFN). Non-D alloantibodies that are capable of causing severe HDFN include anti-K, anti-E, and anti-c. Anti-c is clinically the most important Rh system antibody after anti-D. Here, we report three cases of neonates presenting with anemia and hyperbilirubinemia with strongly positive direct antiglobulin test who required phototherapy and neonatal exchange transfusion due to non-D antibody in RhD positive antenatal women. Anti-c was common in all the three cases while two cases have one additional non-D antibody. Due to faulty practices, antenatal antibody screening was not done for any case considering the mother's RhD positive status. Hence, antenatal antibody screening should be performed routinely, in all RhD positive pregnant women to reduce the delay in diagnosis and the management of HDFN occurring due to non-D antibodies. |
| first_indexed | 2024-04-13T19:35:58Z |
| format | Article |
| id | doaj.art-db69294bd39149ff83f219ab517d85c1 |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-13T19:35:58Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-db69294bd39149ff83f219ab517d85c12022-12-22T02:33:01ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116112112310.4103/ajts.ajts_108_21A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal womenBharat SinghRajendra ChaudharyPreeti ElhenceJyoti Kala BharatiAnubha SrivastavaThe widespread use of anti-D immunoglobulin has resulted in a relative increase in the importance of non-D alloimmunization as a cause of hemolytic disease of the fetus and newborn (HDFN). Non-D alloantibodies that are capable of causing severe HDFN include anti-K, anti-E, and anti-c. Anti-c is clinically the most important Rh system antibody after anti-D. Here, we report three cases of neonates presenting with anemia and hyperbilirubinemia with strongly positive direct antiglobulin test who required phototherapy and neonatal exchange transfusion due to non-D antibody in RhD positive antenatal women. Anti-c was common in all the three cases while two cases have one additional non-D antibody. Due to faulty practices, antenatal antibody screening was not done for any case considering the mother's RhD positive status. Hence, antenatal antibody screening should be performed routinely, in all RhD positive pregnant women to reduce the delay in diagnosis and the management of HDFN occurring due to non-D antibodies.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=121;epage=123;aulast=anti-c antibodyexchange transfusionhemolytic disease of the fetus and newbornmaternal alloimmunizationphototherapy |
| spellingShingle | Bharat Singh Rajendra Chaudhary Preeti Elhence Jyoti Kala Bharati Anubha Srivastava A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women Asian Journal of Transfusion Science anti-c antibody exchange transfusion hemolytic disease of the fetus and newborn maternal alloimmunization phototherapy |
| title | A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women |
| title_full | A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women |
| title_fullStr | A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women |
| title_full_unstemmed | A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women |
| title_short | A case report on non-D HDFN: Highlighting the role of antibody screening in RhD positive antenatal women |
| title_sort | case report on non d hdfn highlighting the role of antibody screening in rhd positive antenatal women |
| topic | anti-c antibody exchange transfusion hemolytic disease of the fetus and newborn maternal alloimmunization phototherapy |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=1;spage=121;epage=123;aulast= |
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