Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives
A series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Baci...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535211002942 |
| _version_ | 1828423232709984256 |
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| author | Habibullah Khalilullah Shamshir Khan Md. Shivli Nomani Bahar Ahmed |
| author_facet | Habibullah Khalilullah Shamshir Khan Md. Shivli Nomani Bahar Ahmed |
| author_sort | Habibullah Khalilullah |
| collection | DOAJ |
| description | A series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans by twofold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs norfloxacin, chloramphenicol and fluconazole, against tested strains. |
| first_indexed | 2024-12-10T15:58:32Z |
| format | Article |
| id | doaj.art-db693eb1cbc7415596a9de96bfbd4605 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-10T15:58:32Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-db693eb1cbc7415596a9de96bfbd46052022-12-22T01:42:33ZengElsevierArabian Journal of Chemistry1878-53522016-11-019S2S1029S103510.1016/j.arabjc.2011.11.009Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivativesHabibullah Khalilullah0Shamshir Khan1Md. Shivli Nomani2Bahar Ahmed3Department of Pharmaceutical Chemistry, Alwar Pharmacy College, Alwar 301 030, Rajasthan, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Qassim University, Buraidah, Saudi ArabiaDepartment of Pharmaceutical Microbiology and Biotechnology, Alwar Pharmacy College, Alwar 301 030, Rajasthan, IndiaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110 062, IndiaA series of 1,3,4-oxadizole derivatives containing 1,4-benzodioxane ring system were synthesized starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesized compounds were characterized and evaluated for antibacterial activity against Staphylococcus aureus, Escherichia coli and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans by twofold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs norfloxacin, chloramphenicol and fluconazole, against tested strains.http://www.sciencedirect.com/science/article/pii/S18785352110029421,4-Benzodioxane1,3,4-OxadiazoleAntibacterialAntifungal |
| spellingShingle | Habibullah Khalilullah Shamshir Khan Md. Shivli Nomani Bahar Ahmed Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives Arabian Journal of Chemistry 1,4-Benzodioxane 1,3,4-Oxadiazole Antibacterial Antifungal |
| title | Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives |
| title_full | Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives |
| title_fullStr | Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives |
| title_full_unstemmed | Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives |
| title_short | Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1,3,4-oxadiazole derivatives |
| title_sort | synthesis characterization and antimicrobial activity of benzodioxane ring containing 1 3 4 oxadiazole derivatives |
| topic | 1,4-Benzodioxane 1,3,4-Oxadiazole Antibacterial Antifungal |
| url | http://www.sciencedirect.com/science/article/pii/S1878535211002942 |
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