Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids
Synthetic cathinones are analogue compounds of the plant based stimulant cathinone. Its use, abuse, and related consumption complications have steadily increased in the last years. For this reason, there is a need for innovative analytical approaches that enable its rapid screening in biological mat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Analytica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4532/3/1/2 |
| _version_ | 1797473316582195200 |
|---|---|
| author | André M. Segurado Samir M. Ahmad Nuno R. Neng Margarida M. Maniés-Sequeira Helena Gaspar José Manuel F. Nogueira |
| author_facet | André M. Segurado Samir M. Ahmad Nuno R. Neng Margarida M. Maniés-Sequeira Helena Gaspar José Manuel F. Nogueira |
| author_sort | André M. Segurado |
| collection | DOAJ |
| description | Synthetic cathinones are analogue compounds of the plant based stimulant cathinone. Its use, abuse, and related consumption complications have steadily increased in the last years. For this reason, there is a need for innovative analytical approaches that enable its rapid screening in biological matrices (e.g., oral fluids). The present work proposes a new analytical methodology by combining bar adsorptive microextraction followed by microliquid desorption and gas chromatography coupled to mass spectrometry (BAµE-µLD/GC-MS) for screening three synthetic cathinones (α-PVP, α-PVT, and MDPV) in oral fluids. The optimization of the BAµE-µLD/GC-MS methodology was successfully applied for the analysis of the target compounds in oral fluids. The results show average recoveries between 43.1 and 52.3% for the three synthetic cathinones. Good selectivity was also noticed. The developed methodology presents itself as an alternative tool to screen these compounds in oral fluids. To the best of our knowledge, this is the first work that combines a microextraction sorption-based technique followed by GC-MS analysis for the screening of synthetic cathinones in oral fluids. |
| first_indexed | 2024-03-09T20:13:02Z |
| format | Article |
| id | doaj.art-db6cc79e198041d5ab06ef4bbecaf665 |
| institution | Directory Open Access Journal |
| issn | 2673-4532 |
| language | English |
| last_indexed | 2024-03-09T20:13:02Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Analytica |
| spelling | doaj.art-db6cc79e198041d5ab06ef4bbecaf6652023-11-24T00:09:10ZengMDPI AGAnalytica2673-45322022-01-0131142310.3390/analytica3010002Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral FluidsAndré M. Segurado0Samir M. Ahmad1Nuno R. Neng2Margarida M. Maniés-Sequeira3Helena Gaspar4José Manuel F. Nogueira5Centro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalBioISI—Biosystems & Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalDepartamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalCentro de Química Estrutural, Institute of Molecular Sciences, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, PortugalSynthetic cathinones are analogue compounds of the plant based stimulant cathinone. Its use, abuse, and related consumption complications have steadily increased in the last years. For this reason, there is a need for innovative analytical approaches that enable its rapid screening in biological matrices (e.g., oral fluids). The present work proposes a new analytical methodology by combining bar adsorptive microextraction followed by microliquid desorption and gas chromatography coupled to mass spectrometry (BAµE-µLD/GC-MS) for screening three synthetic cathinones (α-PVP, α-PVT, and MDPV) in oral fluids. The optimization of the BAµE-µLD/GC-MS methodology was successfully applied for the analysis of the target compounds in oral fluids. The results show average recoveries between 43.1 and 52.3% for the three synthetic cathinones. Good selectivity was also noticed. The developed methodology presents itself as an alternative tool to screen these compounds in oral fluids. To the best of our knowledge, this is the first work that combines a microextraction sorption-based technique followed by GC-MS analysis for the screening of synthetic cathinones in oral fluids.https://www.mdpi.com/2673-4532/3/1/2BAµEGC-MSNMRoral fluidsynthetic cathinonesMDPBP |
| spellingShingle | André M. Segurado Samir M. Ahmad Nuno R. Neng Margarida M. Maniés-Sequeira Helena Gaspar José Manuel F. Nogueira Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids Analytica BAµE GC-MS NMR oral fluid synthetic cathinones MDPBP |
| title | Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids |
| title_full | Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids |
| title_fullStr | Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids |
| title_full_unstemmed | Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids |
| title_short | Simple Analytical Strategy for Screening Three Synthetic Cathinones (α-PVT, α-PVP, and MDPV) in Oral Fluids |
| title_sort | simple analytical strategy for screening three synthetic cathinones α pvt α pvp and mdpv in oral fluids |
| topic | BAµE GC-MS NMR oral fluid synthetic cathinones MDPBP |
| url | https://www.mdpi.com/2673-4532/3/1/2 |
| work_keys_str_mv | AT andremsegurado simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids AT samirmahmad simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids AT nunorneng simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids AT margaridammaniessequeira simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids AT helenagaspar simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids AT josemanuelfnogueira simpleanalyticalstrategyforscreeningthreesyntheticcathinonesapvtapvpandmdpvinoralfluids |