Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features
We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgi...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2015-09-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-49-5-403.pdf |
| _version_ | 1818969078288613376 |
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| author | Miguel Fdo. Salazar María del Rocío Estrada Hernández Erick Gómez Apo Laura G. Chávez Macías Carlos Alfonso Rodríguez Álvarez |
| author_facet | Miguel Fdo. Salazar María del Rocío Estrada Hernández Erick Gómez Apo Laura G. Chávez Macías Carlos Alfonso Rodríguez Álvarez |
| author_sort | Miguel Fdo. Salazar |
| collection | DOAJ |
| description | We report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described. |
| first_indexed | 2024-12-20T14:14:52Z |
| format | Article |
| id | doaj.art-db6ccf5627904aceb107194eefeb05c4 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-20T14:14:52Z |
| publishDate | 2015-09-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-db6ccf5627904aceb107194eefeb05c42022-12-21T19:38:04ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452015-09-0149540340810.4132/jptm.2015.05.2816532Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like FeaturesMiguel Fdo. Salazar0María del Rocío Estrada Hernández1Erick Gómez Apo2Laura G. Chávez Macías3Carlos Alfonso Rodríguez Álvarez4 Anatomical Pathology Division, “Dr. Manuel Gea González” General Hospital, Mexico City, Mexico Anatomical Pathology Division, “Dr. Manuel Gea González” General Hospital, Mexico City, Mexico Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico Pathology Unit, Neuropathology Service, Mexico General Hospital, Mexico City, Mexico Paediatric Neurosurgery, “Legaria” Paediatric Hospital, Mexico City, MexicoWe report a unique case of a 4-year-old girl with an intriguing fibrohistiocytic tumour. Magnetic resonance imaging scans showed a dural mass of variegated intensity compressing the left occipital pole and apparently extending toward the superior sagittal sinus. Grossly, the cut surface of the surgical specimen was yellow, pale, and soft with reddish kernel-like crusts. Histologically, the yellow areas resembled cholesterol granulomas with widespread coagulative necrosis, cholesterol clefts, powdery calcification, foreign body-type giant cells, and foamy macrophages, while the scattered red spots contained numerous multinucleated giant cells of foreign-body and Touton types, the former with amphophilic to slightly eosinophilic cytoplasm. Immunoperoxidase reactions confirmed the expression of histiocytic markers and vimentin. As far as we know, no tumour displaying these peculiar morphological features has yet been described.http://www.jpatholtm.org/upload/pdf/jptm-49-5-403.pdfCNS fibrohistiocytic tumourDural tumourCholesterol granulomaSolitary reticulohistiocytomaFibroxanthoma |
| spellingShingle | Miguel Fdo. Salazar María del Rocío Estrada Hernández Erick Gómez Apo Laura G. Chávez Macías Carlos Alfonso Rodríguez Álvarez Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features Journal of Pathology and Translational Medicine CNS fibrohistiocytic tumour Dural tumour Cholesterol granuloma Solitary reticulohistiocytoma Fibroxanthoma |
| title | Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features |
| title_full | Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features |
| title_fullStr | Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features |
| title_full_unstemmed | Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features |
| title_short | Paediatric Primary Pachymeningeal Xanthogranuloma with Scattered Foci Displaying Reticulohistiocytoma-like Features |
| title_sort | paediatric primary pachymeningeal xanthogranuloma with scattered foci displaying reticulohistiocytoma like features |
| topic | CNS fibrohistiocytic tumour Dural tumour Cholesterol granuloma Solitary reticulohistiocytoma Fibroxanthoma |
| url | http://www.jpatholtm.org/upload/pdf/jptm-49-5-403.pdf |
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