Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway

Anti-Inflammatory Effects of Ginsenoside Rb3 in LPS-Induced Macrophages Through Direct Inhibition of TLR4 Signaling Pathway

Panax ginseng has therapeutic effects on various inflammation-related diseases. Ginsenoside Rb3 (GRb3), a natural compound with anti-inflammatory and immunomodulatory properties, is one of the main active panaxadiol extracted from Panax ginseng. We explored whether GRb3 inhibited LPS-mediated inflam...

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Bibliographic Details
Main Authors: Honglin Xu, Min Liu, Guanghong Chen, Yuting Wu, Lingpeng Xie, Xin Han, Guoyong Zhang, Zhangbin Tan, Wenjun Ding, Huijie Fan, Hongmei Chen, Bin Liu, Yingchun Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
anti-inflammatory effects
ginsenoside Rb3
MAPK
NF-κB
TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.714554/full

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