Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study
Hypersensitivity pneumonitis is an immunologically mediated form of lung disease, resulting from inhalational exposure to a large variety of antigens. A subgroup of patients with fibrotic hypersensitivity pneumonitis (FHP) develop symptomatic, functional and radiographic disease progression. Mortali...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-01-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/1/00625-2023.full |
| _version_ | 1797278869687894016 |
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| author | Evans R. Fernández Pérez Sonia M. Leach Brian Vestal Evans R. Fernández Pérez |
| author_facet | Evans R. Fernández Pérez Sonia M. Leach Brian Vestal Evans R. Fernández Pérez |
| author_sort | Evans R. Fernández Pérez |
| collection | DOAJ |
| description | Hypersensitivity pneumonitis is an immunologically mediated form of lung disease, resulting from inhalational exposure to a large variety of antigens. A subgroup of patients with fibrotic hypersensitivity pneumonitis (FHP) develop symptomatic, functional and radiographic disease progression. Mortality occurs primarily from respiratory failure as a result of progressive and self-sustaining lung injury that often occurs despite immunosuppression and removal of the inciting antigen. The development and validation of a prognostic transcriptomic signature for FHP (PREDICT-HP) is an observational multicentre cohort study designed to explore a transcriptomic signature from peripheral blood mononuclear cells in patients with FHP that is predictive of disease progression. This article describes the design and rationale of the PREDICT-HP study. This study will enrol ∼135 patients with FHP at approximately seven academic medical sites. Participants with a confirmed diagnosis of FHP are followed over 24 months and undergo physical examinations, self-administered questionnaires, chest computed tomography, pulmonary function tests, a 6-min walk test and blood testing for transcriptomic analyses. At each 6-month follow-up visit the study will assess the participants' clinical course and clinical events including hospitalisations and respiratory exacerbations. The PREDICT study has the potential to enhance our ability to predict disease progression and fundamentally advance our understanding of the pathobiology of FHP disease progression. |
| first_indexed | 2024-03-07T16:15:21Z |
| format | Article |
| id | doaj.art-db6e020697584ddbae36b6930d8631be |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-07T16:15:21Z |
| publishDate | 2024-01-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-db6e020697584ddbae36b6930d8631be2024-03-04T11:29:59ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-01-0110110.1183/23120541.00625-202300625-2023Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) studyEvans R. Fernández Pérez0Sonia M. Leach1Brian Vestal2Evans R. Fernández Pérez Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA Hypersensitivity pneumonitis is an immunologically mediated form of lung disease, resulting from inhalational exposure to a large variety of antigens. A subgroup of patients with fibrotic hypersensitivity pneumonitis (FHP) develop symptomatic, functional and radiographic disease progression. Mortality occurs primarily from respiratory failure as a result of progressive and self-sustaining lung injury that often occurs despite immunosuppression and removal of the inciting antigen. The development and validation of a prognostic transcriptomic signature for FHP (PREDICT-HP) is an observational multicentre cohort study designed to explore a transcriptomic signature from peripheral blood mononuclear cells in patients with FHP that is predictive of disease progression. This article describes the design and rationale of the PREDICT-HP study. This study will enrol ∼135 patients with FHP at approximately seven academic medical sites. Participants with a confirmed diagnosis of FHP are followed over 24 months and undergo physical examinations, self-administered questionnaires, chest computed tomography, pulmonary function tests, a 6-min walk test and blood testing for transcriptomic analyses. At each 6-month follow-up visit the study will assess the participants' clinical course and clinical events including hospitalisations and respiratory exacerbations. The PREDICT study has the potential to enhance our ability to predict disease progression and fundamentally advance our understanding of the pathobiology of FHP disease progression.http://openres.ersjournals.com/content/10/1/00625-2023.full |
| spellingShingle | Evans R. Fernández Pérez Sonia M. Leach Brian Vestal Evans R. Fernández Pérez Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study ERJ Open Research |
| title | Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study |
| title_full | Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study |
| title_fullStr | Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study |
| title_full_unstemmed | Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study |
| title_short | Rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis (PREDICT) study |
| title_sort | rationale and design of the prognostic transcriptomic signature in fibrotic hypersensitivity pneumonitis predict study |
| url | http://openres.ersjournals.com/content/10/1/00625-2023.full |
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