Pathogenesis Markers of Hashimoto's Disease—A Mini Review
Hashimoto’s thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-10-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/27/10/10.31083/j.fbl2710297 |
| _version_ | 1828155498833117184 |
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| author | Binghui Jin Shuang Wang Zhe Fan |
| author_facet | Binghui Jin Shuang Wang Zhe Fan |
| author_sort | Binghui Jin |
| collection | DOAJ |
| description | Hashimoto’s thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors, hereditary inclination, trace elements immune factors, cytokines, and DNA and miRNA all play an important role. Herein, we summarize the precision factors involved in the pathogenesis of HT and offer an update over the past 5 years to provide a theoretical basis for further investigation of the relevant targets for HT treatment. |
| first_indexed | 2024-04-11T22:54:54Z |
| format | Article |
| id | doaj.art-db6e342ebba54a2cb52d3a27adfbbf87 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-11T22:54:54Z |
| publishDate | 2022-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-db6e342ebba54a2cb52d3a27adfbbf872022-12-22T03:58:28ZengIMR PressFrontiers in Bioscience-Landmark2768-67012022-10-01271029710.31083/j.fbl2710297S2768-6701(22)00660-8Pathogenesis Markers of Hashimoto's Disease—A Mini ReviewBinghui Jin0Shuang Wang1Zhe Fan2Department of General Surgery, Third People’s Hospital of Dalian, Dalian Medical University, 116033, Dalian, Liaoning, ChinaDepartment of Endocrinology, Second Affiliated Hospital of Dalian Medical University, 116021, Dalian, Liaoning, ChinaDepartment of General Surgery, Third People’s Hospital of Dalian, Dalian Medical University, 116033, Dalian, Liaoning, ChinaHashimoto’s thyroiditis (HT) is the most common autoimmune disease involving the thyroid gland. HT often clinically manifest as hypothyroidism due to the destruction of thyroid cells mediated by humoral and cellular immunity. The pathogenesis of HT is a complex process in which environmental factors, hereditary inclination, trace elements immune factors, cytokines, and DNA and miRNA all play an important role. Herein, we summarize the precision factors involved in the pathogenesis of HT and offer an update over the past 5 years to provide a theoretical basis for further investigation of the relevant targets for HT treatment.https://www.imrpress.com/journal/FBL/27/10/10.31083/j.fbl2710297hashimoto's thyroiditisautoimmunitycytokinespathogenesisenvironmental factorshereditary inclinationtrace elements |
| spellingShingle | Binghui Jin Shuang Wang Zhe Fan Pathogenesis Markers of Hashimoto's Disease—A Mini Review Frontiers in Bioscience-Landmark hashimoto's thyroiditis autoimmunity cytokines pathogenesis environmental factors hereditary inclination trace elements |
| title | Pathogenesis Markers of Hashimoto's Disease—A Mini Review |
| title_full | Pathogenesis Markers of Hashimoto's Disease—A Mini Review |
| title_fullStr | Pathogenesis Markers of Hashimoto's Disease—A Mini Review |
| title_full_unstemmed | Pathogenesis Markers of Hashimoto's Disease—A Mini Review |
| title_short | Pathogenesis Markers of Hashimoto's Disease—A Mini Review |
| title_sort | pathogenesis markers of hashimoto s disease a mini review |
| topic | hashimoto's thyroiditis autoimmunity cytokines pathogenesis environmental factors hereditary inclination trace elements |
| url | https://www.imrpress.com/journal/FBL/27/10/10.31083/j.fbl2710297 |
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