Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice
<i>Amomum villosum Lour.</i> (<i>A. villosum</i>), a comestible medicinal plant, has been traditionally used in China to treat diarrhea, stomach fullness, and abdominal distension. Polysaccharide, the main chemical component of <i>A. villosum</i>, has been shown t...
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MDPI AG
2022-11-01
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| Series: | Foods |
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| author | Donghui Luo Jiao Zeng Jingjing Guan Yuanyuan Xu Rui-Bo Jia Jin Chen Guili Jiang Chunxia Zhou |
| author_facet | Donghui Luo Jiao Zeng Jingjing Guan Yuanyuan Xu Rui-Bo Jia Jin Chen Guili Jiang Chunxia Zhou |
| author_sort | Donghui Luo |
| collection | DOAJ |
| description | <i>Amomum villosum Lour.</i> (<i>A. villosum</i>), a comestible medicinal plant, has been traditionally used in China to treat diarrhea, stomach fullness, and abdominal distension. Polysaccharide, the main chemical component of <i>A. villosum</i>, has been shown to possess potential antioxidant and glycosidase inhibitory activities; however, whether it has anticolitis activity is unknown. The aim of this research was to evaluate the anticolitis effects of <i>A. villosum</i> polysaccharide (AVLP) in BALB/c mice. The results showed that AVLP administration significantly reversed body weight loss, colon shortening and colon weight gain and decreased the levels of proinflammatory cytokines and chemokines in colitis mice (<i>p</i> < 0.05). AVLP administration also maintained intestinal barrier function by the upregulation of ZO-1 protein expression (<i>p</i> < 0.05). In addition, high-throughput sequencing analysis showed that AVLP possessed a great regulatory effect on the growth of <i>Adlercreutzia</i>, <i>Clostridium</i>, <i>Streptococcus</i>, <i>Parabacteroides</i>, <i>Helicobacter</i>, <i>Odoribacter,</i> and <i>Alistipes</i> (<i>p</i> < 0.05, LDA score > 2). The correlation analysis revealed that the protective effects against colitis of AVLP were highly correlated with intestinal bacterium regulation. These results suggest that AVLP intake could serve as a prospective nutritional strategy for inflammatory bowel diseases. |
| first_indexed | 2024-03-09T18:20:03Z |
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| id | doaj.art-db730aebe5b44c5f9d142ae1fafd6c05 |
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| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T18:20:03Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-db730aebe5b44c5f9d142ae1fafd6c052023-11-24T08:23:34ZengMDPI AGFoods2304-81582022-11-011122373710.3390/foods11223737Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c MiceDonghui Luo0Jiao Zeng1Jingjing Guan2Yuanyuan Xu3Rui-Bo Jia4Jin Chen5Guili Jiang6Chunxia Zhou7School of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaChaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory, Chaozhou 521000, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, ChinaSchool of Food Science and Engineering, Guangdong Ocean University, Yangjiang 529500, China<i>Amomum villosum Lour.</i> (<i>A. villosum</i>), a comestible medicinal plant, has been traditionally used in China to treat diarrhea, stomach fullness, and abdominal distension. Polysaccharide, the main chemical component of <i>A. villosum</i>, has been shown to possess potential antioxidant and glycosidase inhibitory activities; however, whether it has anticolitis activity is unknown. The aim of this research was to evaluate the anticolitis effects of <i>A. villosum</i> polysaccharide (AVLP) in BALB/c mice. The results showed that AVLP administration significantly reversed body weight loss, colon shortening and colon weight gain and decreased the levels of proinflammatory cytokines and chemokines in colitis mice (<i>p</i> < 0.05). AVLP administration also maintained intestinal barrier function by the upregulation of ZO-1 protein expression (<i>p</i> < 0.05). In addition, high-throughput sequencing analysis showed that AVLP possessed a great regulatory effect on the growth of <i>Adlercreutzia</i>, <i>Clostridium</i>, <i>Streptococcus</i>, <i>Parabacteroides</i>, <i>Helicobacter</i>, <i>Odoribacter,</i> and <i>Alistipes</i> (<i>p</i> < 0.05, LDA score > 2). The correlation analysis revealed that the protective effects against colitis of AVLP were highly correlated with intestinal bacterium regulation. These results suggest that AVLP intake could serve as a prospective nutritional strategy for inflammatory bowel diseases.https://www.mdpi.com/2304-8158/11/22/3737<i>Amomum villosum Lour.</i> polysaccharideulcerative colitisgut flora |
| spellingShingle | Donghui Luo Jiao Zeng Jingjing Guan Yuanyuan Xu Rui-Bo Jia Jin Chen Guili Jiang Chunxia Zhou Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice Foods <i>Amomum villosum Lour.</i> polysaccharide ulcerative colitis gut flora |
| title | Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice |
| title_full | Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice |
| title_fullStr | Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice |
| title_full_unstemmed | Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice |
| title_short | Dietary Supplement of <i>Amomum villosum Lour.</i> Polysaccharide Attenuates Ulcerative Colitis in BALB/c Mice |
| title_sort | dietary supplement of i amomum villosum lour i polysaccharide attenuates ulcerative colitis in balb c mice |
| topic | <i>Amomum villosum Lour.</i> polysaccharide ulcerative colitis gut flora |
| url | https://www.mdpi.com/2304-8158/11/22/3737 |
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