Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration
The tremendous personal and economic burden worldwide caused by low back pain (LBP) has been surging in recent years. While intervertebral disc degeneration (IVDD) is the leading cause of LBP and vast efforts have been made to develop effective therapies, this problem is far from being resolved, as...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/6/713 |
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| author | Yu-Dong Zhao Yong-Can Huang Jia-Liang Lin Wei-Shi Li |
| author_facet | Yu-Dong Zhao Yong-Can Huang Jia-Liang Lin Wei-Shi Li |
| author_sort | Yu-Dong Zhao |
| collection | DOAJ |
| description | The tremendous personal and economic burden worldwide caused by low back pain (LBP) has been surging in recent years. While intervertebral disc degeneration (IVDD) is the leading cause of LBP and vast efforts have been made to develop effective therapies, this problem is far from being resolved, as most treatments, such as painkillers and surgeries, mainly focus on relieving the symptoms rather than reversing the cause of IVDD. However, as stem/progenitor cells possess the potential to regenerate IVD, a deeper understanding of the early development and role of these cells could help to improve the effectiveness of stem/progenitor cell therapy in treating LBP. Single-cell RNA sequencing results provide fresh insights into the heterogeneity and development patterns of IVD progenitors; additionally, we compare mesenchymal stromal cells and IVD progenitors to provide a clearer view of the optimal cell source proposed for IVD regeneration. |
| first_indexed | 2024-03-11T02:46:15Z |
| format | Article |
| id | doaj.art-db741e0205b94650a3e9cdbb05fd9635 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-11T02:46:15Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-db741e0205b94650a3e9cdbb05fd96352023-11-18T09:21:43ZengMDPI AGBioengineering2306-53542023-06-0110671310.3390/bioengineering10060713Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc RegenerationYu-Dong Zhao0Yong-Can Huang1Jia-Liang Lin2Wei-Shi Li3Department of Orthopaedics, Peking University Third Hospital, Beijing 100191, ChinaShenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, ChinaDepartment of Orthopaedics, Peking University Third Hospital, Beijing 100191, ChinaDepartment of Orthopaedics, Peking University Third Hospital, Beijing 100191, ChinaThe tremendous personal and economic burden worldwide caused by low back pain (LBP) has been surging in recent years. While intervertebral disc degeneration (IVDD) is the leading cause of LBP and vast efforts have been made to develop effective therapies, this problem is far from being resolved, as most treatments, such as painkillers and surgeries, mainly focus on relieving the symptoms rather than reversing the cause of IVDD. However, as stem/progenitor cells possess the potential to regenerate IVD, a deeper understanding of the early development and role of these cells could help to improve the effectiveness of stem/progenitor cell therapy in treating LBP. Single-cell RNA sequencing results provide fresh insights into the heterogeneity and development patterns of IVD progenitors; additionally, we compare mesenchymal stromal cells and IVD progenitors to provide a clearer view of the optimal cell source proposed for IVD regeneration.https://www.mdpi.com/2306-5354/10/6/713intervertebral discprogenitorssingle-cell RNA sequencingregeneration |
| spellingShingle | Yu-Dong Zhao Yong-Can Huang Jia-Liang Lin Wei-Shi Li Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration Bioengineering intervertebral disc progenitors single-cell RNA sequencing regeneration |
| title | Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration |
| title_full | Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration |
| title_fullStr | Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration |
| title_full_unstemmed | Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration |
| title_short | Intervertebral Disc Progenitors: Lessons Learned from Single-Cell RNA Sequencing and the Role in Intervertebral Disc Regeneration |
| title_sort | intervertebral disc progenitors lessons learned from single cell rna sequencing and the role in intervertebral disc regeneration |
| topic | intervertebral disc progenitors single-cell RNA sequencing regeneration |
| url | https://www.mdpi.com/2306-5354/10/6/713 |
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