Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study
IntroductionThis study aimed to assess the correlation between the blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio and adverse outcomes (AOs) at 3 months in patients with acute ischemic stroke (AIS) in the Korean population.MethodsThis cohort study encompassed 1906 cases of AIS at a South Kor...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-04-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1350116/full |
| _version_ | 1797202917334188032 |
|---|---|
| author | Hongjuan Liu Yongjun Chen Quan Zhou Guixiang Guo Bohong Hu Fangchao Wan Jun Wen |
| author_facet | Hongjuan Liu Yongjun Chen Quan Zhou Guixiang Guo Bohong Hu Fangchao Wan Jun Wen |
| author_sort | Hongjuan Liu |
| collection | DOAJ |
| description | IntroductionThis study aimed to assess the correlation between the blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio and adverse outcomes (AOs) at 3 months in patients with acute ischemic stroke (AIS) in the Korean population.MethodsThis cohort study encompassed 1906 cases of AIS at a South Korean hospital from January 2010 to December 2016. To determine the linear correlation between the BUN/Cr ratio and AOs in AIS, a binary logistic regression model (BLRM) was employed. Additionally, generalized additive models and techniques for smooth curve fitting were utilized to reveal the nonlinear dynamics between the BUN/Cr ratio and AOs in patients with AIS.ResultsThe prevalence of AOs was 28.65%, with a median BUN/Cr ratio of 18.96. Following adjustments for covariates, the BLRM disclosed that the association between the BUN/Cr ratio and the risk of AOs in patients with AIS did not attain statistical significance. Nevertheless, a nonlinear relationship surfaced, pinpointing an inflection point at 21.591. To the left of this inflection point, a 31.42% reduction in the risk of AOs was noted for every 1-unit surge in the Z score of the BUN/Cr ratio [odds ratio (OR) = 0.686, 95% confidence interval (CI): 0.519, 0.906, p = 0.008]. On the right side of the inflection point, the effect size (OR = 1.405, 95% CI: 1.018, 1.902, p = 0.039) was determined.ConclusionThe findings of this study underscore the intricate nature of the relationship between the BUN/Cr ratio and 3-month outcomes in patients with AIS, establishing a robust groundwork for future investigations. |
| first_indexed | 2024-04-24T08:11:03Z |
| format | Article |
| id | doaj.art-db74f5bf622844b7823b2bd40d7619d1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T08:11:03Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-db74f5bf622844b7823b2bd40d7619d12024-04-17T04:59:57ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-04-011510.3389/fneur.2024.13501161350116Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort studyHongjuan LiuYongjun ChenQuan ZhouGuixiang GuoBohong HuFangchao WanJun WenIntroductionThis study aimed to assess the correlation between the blood urea nitrogen (BUN)-to-creatinine (BUN/Cr) ratio and adverse outcomes (AOs) at 3 months in patients with acute ischemic stroke (AIS) in the Korean population.MethodsThis cohort study encompassed 1906 cases of AIS at a South Korean hospital from January 2010 to December 2016. To determine the linear correlation between the BUN/Cr ratio and AOs in AIS, a binary logistic regression model (BLRM) was employed. Additionally, generalized additive models and techniques for smooth curve fitting were utilized to reveal the nonlinear dynamics between the BUN/Cr ratio and AOs in patients with AIS.ResultsThe prevalence of AOs was 28.65%, with a median BUN/Cr ratio of 18.96. Following adjustments for covariates, the BLRM disclosed that the association between the BUN/Cr ratio and the risk of AOs in patients with AIS did not attain statistical significance. Nevertheless, a nonlinear relationship surfaced, pinpointing an inflection point at 21.591. To the left of this inflection point, a 31.42% reduction in the risk of AOs was noted for every 1-unit surge in the Z score of the BUN/Cr ratio [odds ratio (OR) = 0.686, 95% confidence interval (CI): 0.519, 0.906, p = 0.008]. On the right side of the inflection point, the effect size (OR = 1.405, 95% CI: 1.018, 1.902, p = 0.039) was determined.ConclusionThe findings of this study underscore the intricate nature of the relationship between the BUN/Cr ratio and 3-month outcomes in patients with AIS, establishing a robust groundwork for future investigations.https://www.frontiersin.org/articles/10.3389/fneur.2024.1350116/fullblood urea nitrogencreatininestrokeadverse outcomescohort study |
| spellingShingle | Hongjuan Liu Yongjun Chen Quan Zhou Guixiang Guo Bohong Hu Fangchao Wan Jun Wen Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study Frontiers in Neurology blood urea nitrogen creatinine stroke adverse outcomes cohort study |
| title | Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study |
| title_full | Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study |
| title_fullStr | Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study |
| title_full_unstemmed | Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study |
| title_short | Association between the blood urea nitrogen-to-creatinine ratio and 3-month outcomes in patients with acute ischemic stroke: a secondary analysis based on a prospective cohort study |
| title_sort | association between the blood urea nitrogen to creatinine ratio and 3 month outcomes in patients with acute ischemic stroke a secondary analysis based on a prospective cohort study |
| topic | blood urea nitrogen creatinine stroke adverse outcomes cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1350116/full |
| work_keys_str_mv | AT hongjuanliu associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT yongjunchen associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT quanzhou associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT guixiangguo associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT bohonghu associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT fangchaowan associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy AT junwen associationbetweenthebloodureanitrogentocreatinineratioand3monthoutcomesinpatientswithacuteischemicstrokeasecondaryanalysisbasedonaprospectivecohortstudy |