Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure
Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biolo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034124000200 |
| _version_ | 1797249178271744000 |
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| author | Sadiya Bi Shaikh Ashwini Prabhu Akarsha B. Mohamudha Parveen Rahamathulla Mohemmed Sha Yashodhar Prabhakar Bhandary |
| author_facet | Sadiya Bi Shaikh Ashwini Prabhu Akarsha B. Mohamudha Parveen Rahamathulla Mohemmed Sha Yashodhar Prabhakar Bhandary |
| author_sort | Sadiya Bi Shaikh |
| collection | DOAJ |
| description | Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biology and pathogenicity of this virus to design better treatment modalities. Existing antiretroviral drugs remain partially ineffective in critical subjects with associated co-morbidities. This review provides an insight into the molecular mechanisms by which SARS-CoV2 targets the lungs leading to ARDS in severe cases. This also addresses the possible drug targets and certain anti-inflammatory natural compounds that can be looked upon as promising adjuvant therapeutics for COVID-19. |
| first_indexed | 2024-03-08T00:01:13Z |
| format | Article |
| id | doaj.art-db75a51de04b4e9183eb93a1aa0d3207 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-24T20:26:21Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-db75a51de04b4e9183eb93a1aa0d32072024-03-22T05:38:56ZengElsevierJournal of Infection and Public Health1876-03412024-04-01174573578Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cureSadiya Bi Shaikh0Ashwini Prabhu1 Akarsha B.2Mohamudha Parveen Rahamathulla3Mohemmed Sha4Yashodhar Prabhakar Bhandary5Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore 575 018, Karnataka, IndiaYenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore 575 018, Karnataka, IndiaYenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore 575 018, Karnataka, IndiaDepartment of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Kingdom of Saudi Arabia; Corresponding authors.Department of Software Engineering, College of Computer Engineering and Sciences, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Kingdom of Saudi ArabiaYenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore 575 018, Karnataka, India; Corresponding authors.Novel coronavirus (SARS nCoV2), belonging to the family coronaviridae, remains a dreadful pathogen affecting the respiratory tract and lungs. COVID-19 declared a global pandemic by WHO, has become a serious cause of concern for clinicians and researchers, who need to understand the significant biology and pathogenicity of this virus to design better treatment modalities. Existing antiretroviral drugs remain partially ineffective in critical subjects with associated co-morbidities. This review provides an insight into the molecular mechanisms by which SARS-CoV2 targets the lungs leading to ARDS in severe cases. This also addresses the possible drug targets and certain anti-inflammatory natural compounds that can be looked upon as promising adjuvant therapeutics for COVID-19.http://www.sciencedirect.com/science/article/pii/S1876034124000200SARS-CoV2COVID-19LungInflammationNatural compounds |
| spellingShingle | Sadiya Bi Shaikh Ashwini Prabhu Akarsha B. Mohamudha Parveen Rahamathulla Mohemmed Sha Yashodhar Prabhakar Bhandary Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure Journal of Infection and Public Health SARS-CoV2 COVID-19 Lung Inflammation Natural compounds |
| title | Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure |
| title_full | Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure |
| title_fullStr | Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure |
| title_full_unstemmed | Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure |
| title_short | Lung as a target for COVID-19: Mechanistic insights and probable candidate molecules for cure |
| title_sort | lung as a target for covid 19 mechanistic insights and probable candidate molecules for cure |
| topic | SARS-CoV2 COVID-19 Lung Inflammation Natural compounds |
| url | http://www.sciencedirect.com/science/article/pii/S1876034124000200 |
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