Mining the bacterial genome to discover new antimicrobial molecules
Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome databa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2022-02-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.202115409 |
| _version_ | 1797287865154011136 |
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| author | Wenjie Liang Julien Diana |
| author_facet | Wenjie Liang Julien Diana |
| author_sort | Wenjie Liang |
| collection | DOAJ |
| description | Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti‐infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug‐resistant bacteria. |
| first_indexed | 2024-03-07T18:40:54Z |
| format | Article |
| id | doaj.art-db7659e43b51440c92c79c554c33cb87 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T18:40:54Z |
| publishDate | 2022-02-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-db7659e43b51440c92c79c554c33cb872024-03-02T03:58:20ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842022-02-01142n/an/a10.15252/emmm.202115409Mining the bacterial genome to discover new antimicrobial moleculesWenjie Liang0Julien Diana1Institut Necker Enfants Malades (INEM) Institut National de la Santé et de la Recherche Médicale (INSERM) Centre National de la Recherche Scientifique (CNRS) Université de Paris Paris FranceInstitut Necker Enfants Malades (INEM) Institut National de la Santé et de la Recherche Médicale (INSERM) Centre National de la Recherche Scientifique (CNRS) Université de Paris Paris FranceMultidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti‐infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug‐resistant bacteria.https://doi.org/10.15252/emmm.202115409 |
| spellingShingle | Wenjie Liang Julien Diana Mining the bacterial genome to discover new antimicrobial molecules EMBO Molecular Medicine |
| title | Mining the bacterial genome to discover new antimicrobial molecules |
| title_full | Mining the bacterial genome to discover new antimicrobial molecules |
| title_fullStr | Mining the bacterial genome to discover new antimicrobial molecules |
| title_full_unstemmed | Mining the bacterial genome to discover new antimicrobial molecules |
| title_short | Mining the bacterial genome to discover new antimicrobial molecules |
| title_sort | mining the bacterial genome to discover new antimicrobial molecules |
| url | https://doi.org/10.15252/emmm.202115409 |
| work_keys_str_mv | AT wenjieliang miningthebacterialgenometodiscovernewantimicrobialmolecules AT juliendiana miningthebacterialgenometodiscovernewantimicrobialmolecules |