Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease
Abstract Background Inflammatory reaction is an essential factor in the occurrence, development and prognosis of femoropopliteal disease (FPD). The ratio of platelets to lymphocytes (PLR) is a new indicator reflecting platelet aggregation and burden of systemic inflammation. Our study is to explore...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-019-01314-1 |
| _version_ | 1818419179301109760 |
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| author | Yanhua Zhen Zhihui Chang Zhaoyu Liu Jiahe Zheng |
| author_facet | Yanhua Zhen Zhihui Chang Zhaoyu Liu Jiahe Zheng |
| author_sort | Yanhua Zhen |
| collection | DOAJ |
| description | Abstract Background Inflammatory reaction is an essential factor in the occurrence, development and prognosis of femoropopliteal disease (FPD). The ratio of platelets to lymphocytes (PLR) is a new indicator reflecting platelet aggregation and burden of systemic inflammation. Our study is to explore the association between preoperative platelet-to-lymphocyte ratio (pre-PLR) and 6-month primary patency (PP) after drug-coated balloon (DCB) in FPD. Methods There were 70 patients who underwent DCB for FPD contained in the study. According to 6-month PP, patients were divided into group A (PP ≥6 months, n = 54) and group B (PP < 6 months, n = 16). Logistic regression analysis was used to identify potential predictors for 6-month PP after DCB in FPD. A receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of pre-PLR to predict 6-month PP. Results Logistic regression analysis showed that pre-PLR (OR: 1.008, 95% CI: 1.001–1.016, P = 0.031) and lesion length > 10 cm (OR: 4.305, 95% CI: 1.061–17.465, P = 0.041) were independently predictive for 6-month PP. The cutoff value of pre-PLR obtained from the ROC analysis was 127.35 to determine 6-month PP with the area of 0.839. Subgroup analysis was conducted based on the cutoff value of pre-PLR. The 6-month PP in the group of pre-PLR < 127.35 was higher than that of pre-PLR ≥ 127.35 group (p < 0.001). Conclusions The present study indicated that an elevated pre-PLR was an effective additional indicator for predicting early PP in FPD after DCB. |
| first_indexed | 2024-12-14T12:34:27Z |
| format | Article |
| id | doaj.art-db7950e320b94beabe483894c66ea25e |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-14T12:34:27Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-db7950e320b94beabe483894c66ea25e2022-12-21T23:01:06ZengBMCBMC Cardiovascular Disorders1471-22612020-01-012011610.1186/s12872-019-01314-1Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal diseaseYanhua Zhen0Zhihui Chang1Zhaoyu Liu2Jiahe Zheng3Department of Radiology, Shengjing Hospital of China Medical UniversityDepartment of Radiology, Shengjing Hospital of China Medical UniversityDepartment of Radiology, Shengjing Hospital of China Medical UniversityDepartment of Radiology, Shengjing Hospital of China Medical UniversityAbstract Background Inflammatory reaction is an essential factor in the occurrence, development and prognosis of femoropopliteal disease (FPD). The ratio of platelets to lymphocytes (PLR) is a new indicator reflecting platelet aggregation and burden of systemic inflammation. Our study is to explore the association between preoperative platelet-to-lymphocyte ratio (pre-PLR) and 6-month primary patency (PP) after drug-coated balloon (DCB) in FPD. Methods There were 70 patients who underwent DCB for FPD contained in the study. According to 6-month PP, patients were divided into group A (PP ≥6 months, n = 54) and group B (PP < 6 months, n = 16). Logistic regression analysis was used to identify potential predictors for 6-month PP after DCB in FPD. A receiver operating characteristic (ROC) curve analysis was used to identify the cut-off value of pre-PLR to predict 6-month PP. Results Logistic regression analysis showed that pre-PLR (OR: 1.008, 95% CI: 1.001–1.016, P = 0.031) and lesion length > 10 cm (OR: 4.305, 95% CI: 1.061–17.465, P = 0.041) were independently predictive for 6-month PP. The cutoff value of pre-PLR obtained from the ROC analysis was 127.35 to determine 6-month PP with the area of 0.839. Subgroup analysis was conducted based on the cutoff value of pre-PLR. The 6-month PP in the group of pre-PLR < 127.35 was higher than that of pre-PLR ≥ 127.35 group (p < 0.001). Conclusions The present study indicated that an elevated pre-PLR was an effective additional indicator for predicting early PP in FPD after DCB.https://doi.org/10.1186/s12872-019-01314-1PlateletLymphocyteFemoropopliteal diseaseDrug-coated balloonPrimary patency |
| spellingShingle | Yanhua Zhen Zhihui Chang Zhaoyu Liu Jiahe Zheng Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease BMC Cardiovascular Disorders Platelet Lymphocyte Femoropopliteal disease Drug-coated balloon Primary patency |
| title | Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease |
| title_full | Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease |
| title_fullStr | Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease |
| title_full_unstemmed | Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease |
| title_short | Platelet to lymphocyte ratio predicting 6-month primary patency of drug-coated balloon for femoropopliteal disease |
| title_sort | platelet to lymphocyte ratio predicting 6 month primary patency of drug coated balloon for femoropopliteal disease |
| topic | Platelet Lymphocyte Femoropopliteal disease Drug-coated balloon Primary patency |
| url | https://doi.org/10.1186/s12872-019-01314-1 |
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