Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis
Liver fibrosis is the common consequence of various chronic liver injuries and is mainly characterized by the imbalance between the production and degradation of extracellular matrix, which leads to the accumulation of interstitial collagen and other matrix components. Matrix metalloproteinases (MMP...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002603 |
| _version_ | 1797857716118487040 |
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| author | Liang Shan Fengling Wang Dandan Zhai Xiangyun Meng Jianjun Liu Xiongwen Lv |
| author_facet | Liang Shan Fengling Wang Dandan Zhai Xiangyun Meng Jianjun Liu Xiongwen Lv |
| author_sort | Liang Shan |
| collection | DOAJ |
| description | Liver fibrosis is the common consequence of various chronic liver injuries and is mainly characterized by the imbalance between the production and degradation of extracellular matrix, which leads to the accumulation of interstitial collagen and other matrix components. Matrix metalloproteinases (MMPs) and their specific inhibitors, that is, tissue inhibitors of metalloproteinases (TIMPs), play a crucial role in collagen synthesis and lysis. Previous in vivo and in vitro studies of our laboratory found repressing extracellular matrix (ECM) accumulation by restoring the balance between MMPs and TIMPs can alleviate liver fibrosis. We conducted a review of articles published in PubMed and Science Direct in the last decade until February 1, 2023, which were searched for using these words “MMPs/TIMPs” and “Hepatic Fibrosis.” Through a literature review, this article reviews the experimental studies of liver fibrosis based on MMPs/TIMPs, summarizes the components that may exert an anti-liver fibrosis effect by affecting the expression or activity of MMPs/TIMPs, and attempts to clarify the mechanism of MMPs/TIMPs in regulating collagen homeostasis, so as to provide support for the development of anti-liver fibrosis drugs. We found the MMP-TIMP-ECM interaction can result in better understanding of the pathogenesis and progression of hepatic fibrosis from a different angle, and targeting this interaction may be a promising therapeutic strategy for hepatic fibrosis. Additionally, we summarized and analyzed the drugs that have been found to reduce liver fibrosis by changing the ratio of MMPs/TIMPs, including medicine natural products. |
| first_indexed | 2024-04-09T21:02:22Z |
| format | Article |
| id | doaj.art-db79ff3a7b0b478fb504825ef16f05cb |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:02:22Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-db79ff3a7b0b478fb504825ef16f05cb2023-03-29T09:22:33ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114472Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosisLiang Shan0Fengling Wang1Dandan Zhai2Xiangyun Meng3Jianjun Liu4Xiongwen Lv5Department of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei 230032, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, China; The Key Laboratory of Major Autoimmune Diseases, Hefei 230032, Anhui, ChinaDepartment of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, ChinaDepartment of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, ChinaDepartment of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, ChinaDepartment of Pharmacy, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230011, China; Correspondence to: Department of Pharmacy, Hefei Hospital Affiliated to Anhui Medical University (The 2nd People's Hospital of Hefei), Hefei 230011, China.Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, Hefei 230032, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei 230032, China; The Key Laboratory of Major Autoimmune Diseases, Hefei 230032, Anhui, China; Correspondence to: School of Pharmacy, Anhui Medical University, 81 Mei Shan Road, Hefei 230032, China.Liver fibrosis is the common consequence of various chronic liver injuries and is mainly characterized by the imbalance between the production and degradation of extracellular matrix, which leads to the accumulation of interstitial collagen and other matrix components. Matrix metalloproteinases (MMPs) and their specific inhibitors, that is, tissue inhibitors of metalloproteinases (TIMPs), play a crucial role in collagen synthesis and lysis. Previous in vivo and in vitro studies of our laboratory found repressing extracellular matrix (ECM) accumulation by restoring the balance between MMPs and TIMPs can alleviate liver fibrosis. We conducted a review of articles published in PubMed and Science Direct in the last decade until February 1, 2023, which were searched for using these words “MMPs/TIMPs” and “Hepatic Fibrosis.” Through a literature review, this article reviews the experimental studies of liver fibrosis based on MMPs/TIMPs, summarizes the components that may exert an anti-liver fibrosis effect by affecting the expression or activity of MMPs/TIMPs, and attempts to clarify the mechanism of MMPs/TIMPs in regulating collagen homeostasis, so as to provide support for the development of anti-liver fibrosis drugs. We found the MMP-TIMP-ECM interaction can result in better understanding of the pathogenesis and progression of hepatic fibrosis from a different angle, and targeting this interaction may be a promising therapeutic strategy for hepatic fibrosis. Additionally, we summarized and analyzed the drugs that have been found to reduce liver fibrosis by changing the ratio of MMPs/TIMPs, including medicine natural products.http://www.sciencedirect.com/science/article/pii/S0753332223002603Matrix metalloproteinaseTissue inhibitors of metalloproteinaseExtracellular matrixCollagenImmunoregulationHepatic fibrosis |
| spellingShingle | Liang Shan Fengling Wang Dandan Zhai Xiangyun Meng Jianjun Liu Xiongwen Lv Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis Biomedicine & Pharmacotherapy Matrix metalloproteinase Tissue inhibitors of metalloproteinase Extracellular matrix Collagen Immunoregulation Hepatic fibrosis |
| title | Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| title_full | Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| title_fullStr | Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| title_full_unstemmed | Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| title_short | Matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| title_sort | matrix metalloproteinases induce extracellular matrix degradation through various pathways to alleviate hepatic fibrosis |
| topic | Matrix metalloproteinase Tissue inhibitors of metalloproteinase Extracellular matrix Collagen Immunoregulation Hepatic fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002603 |
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