How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?
(1) Background: <i>Aspergillus</i> produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/6/576 |
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| author | Pablo González-García Montserrat Alonso-Sardón Beatriz Rodríguez-Alonso Hugo Almeida Ángela Romero-Alegría Víctor-José Vega-Rodríguez Amparo López-Bernús Juan Luis Muñoz-Bellido Antonio Muro Javier Pardo-Lledías Moncef Belhassen-García |
| author_facet | Pablo González-García Montserrat Alonso-Sardón Beatriz Rodríguez-Alonso Hugo Almeida Ángela Romero-Alegría Víctor-José Vega-Rodríguez Amparo López-Bernús Juan Luis Muñoz-Bellido Antonio Muro Javier Pardo-Lledías Moncef Belhassen-García |
| author_sort | Pablo González-García |
| collection | DOAJ |
| description | (1) Background: <i>Aspergillus</i> produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997–1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19. |
| first_indexed | 2024-03-09T23:22:53Z |
| format | Article |
| id | doaj.art-db7a0fc8a822439e9b6330a859d9757f |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T23:22:53Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-db7a0fc8a822439e9b6330a859d9757f2023-11-23T17:24:23ZengMDPI AGJournal of Fungi2309-608X2022-05-018657610.3390/jof8060576How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?Pablo González-García0Montserrat Alonso-Sardón1Beatriz Rodríguez-Alonso2Hugo Almeida3Ángela Romero-Alegría4Víctor-José Vega-Rodríguez5Amparo López-Bernús6Juan Luis Muñoz-Bellido7Antonio Muro8Javier Pardo-Lledías9Moncef Belhassen-García10Servicio de Medicina Interna, Hospital Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, 39008 Santander, SpainÁrea de Medicina Preventiva, Epidemiología y Salud Pública, IBSAL, CIETUS, Universidad de Salamanca, 37007 Salamanca, SpainServicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, SpainServiçio de Medicina Interna, Unidade Local de Saúde de Guarda, 6300 Guarda, PortugalServicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, SpainServicio de Medicina Interna, CAUSA, 37007 Salamanca, SpainServicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, SpainServicio de Microbiología y Parasitología, CAUSA, CIETUS, IBSAL, Departamento de Ciencias Biomédicas y del Diagnóstico, Universidad de Salamanca, CSIC, 37007 Salamanca, SpainInfectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS, Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, SpainServicio de Medicina Interna, Hospital Marqués de Valdecilla, IDIVAL, Universidad de Cantabria, 39008 Santander, SpainServicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, Spain(1) Background: <i>Aspergillus</i> produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997–1998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.https://www.mdpi.com/2309-608X/8/6/576aspergillosishuman aspergillosisinvasive fungal diseasescase fatality rateSpain |
| spellingShingle | Pablo González-García Montserrat Alonso-Sardón Beatriz Rodríguez-Alonso Hugo Almeida Ángela Romero-Alegría Víctor-José Vega-Rodríguez Amparo López-Bernús Juan Luis Muñoz-Bellido Antonio Muro Javier Pardo-Lledías Moncef Belhassen-García How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? Journal of Fungi aspergillosis human aspergillosis invasive fungal diseases case fatality rate Spain |
| title | How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? |
| title_full | How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? |
| title_fullStr | How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? |
| title_full_unstemmed | How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? |
| title_short | How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain? |
| title_sort | how has the aspergillosis case fatality rate changed over the last two decades in spain |
| topic | aspergillosis human aspergillosis invasive fungal diseases case fatality rate Spain |
| url | https://www.mdpi.com/2309-608X/8/6/576 |
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