Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer
Chelsea Seguin,1 Natalie Kovacevich,1 Ioannis A Voutsadakis,2,3 1Clinical Trials Unit, 2Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste. Marie, 3Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Background: As taxane...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-01-01
|
| Series: | Breast Cancer: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/docetaxel-associated-myalgiandasharthralgia-syndrome-in-patients-with--peer-reviewed-article-BCTT |
| _version_ | 1818926725649661952 |
|---|---|
| author | Seguin C Kovacevich N Voutsadakis IA |
| author_facet | Seguin C Kovacevich N Voutsadakis IA |
| author_sort | Seguin C |
| collection | DOAJ |
| description | Chelsea Seguin,1 Natalie Kovacevich,1 Ioannis A Voutsadakis,2,3 1Clinical Trials Unit, 2Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste. Marie, 3Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Background: As taxanes are increasingly used in oncology, the myalgia–arthralgia syndrome (M-AS) that represents an adverse effect of these drugs is becoming more common. Nevertheless, information regarding predisposing factors, prevention, and therapy of the syndrome is still lacking. Patients and methods: Women who had received docetaxel as part of the FEC-D(T) regimen for the adjuvant treatment of breast cancer were retrospectively identified from the records of our oncology department. Data on demographics, disease specifics, adverse effects, and treatment were reviewed. Patients were divided into two groups: those who developed M-AS after docetaxel treatment and those who did not develop the syndrome. The two groups were compared to identify risk factors for M-AS. Effectiveness of drugs used for M-AS was evaluated. Results: Sixty-seven patients were identified as fulfilling the inclusion criteria. Nineteen patients developed the M-AS after the first docetaxel administration. Forty-eight patients did not develop the syndrome. Three patients in this group were excluded because they had been taking gabapentin or pregabalin at the time of docetaxel administration for another indication. The remaining 45 patients constituted the control group. The two groups were similar in age, menopause status, stage of their cancer, and histology. The M-AS group had a higher median body surface area and was more likely to receive less than the three intended cycles of docetaxel. Nonsteroidal anti-inflammatory drugs, atypical antiepileptics, extended corticosteroids, and opioids were drugs used as M-AS treatments. Conclusion: Docetaxel-associated M-AS is an adverse effect causing incomplete drug treatment. Possible risk factors and effectiveness of treatments for the syndrome are presented. Keywords: myalgia–arthralgia syndrome, taxanes, gabapentin, pregabalin, adverse effects |
| first_indexed | 2024-12-20T03:01:41Z |
| format | Article |
| id | doaj.art-db7a705aa7fb4ebfad9b589e7589b71a |
| institution | Directory Open Access Journal |
| issn | 1179-1314 |
| language | English |
| last_indexed | 2024-12-20T03:01:41Z |
| publishDate | 2017-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Breast Cancer: Targets and Therapy |
| spelling | doaj.art-db7a705aa7fb4ebfad9b589e7589b71a2022-12-21T19:55:44ZengDove Medical PressBreast Cancer: Targets and Therapy1179-13142017-01-01Volume 9394430968Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancerSeguin CKovacevich NVoutsadakis IAChelsea Seguin,1 Natalie Kovacevich,1 Ioannis A Voutsadakis,2,3 1Clinical Trials Unit, 2Division of Medical Oncology, Department of Internal Medicine, Sault Area Hospital, Sault Ste. Marie, 3Division of Clinical Sciences, Northern Ontario School of Medicine, Sudbury, ON, Canada Background: As taxanes are increasingly used in oncology, the myalgia–arthralgia syndrome (M-AS) that represents an adverse effect of these drugs is becoming more common. Nevertheless, information regarding predisposing factors, prevention, and therapy of the syndrome is still lacking. Patients and methods: Women who had received docetaxel as part of the FEC-D(T) regimen for the adjuvant treatment of breast cancer were retrospectively identified from the records of our oncology department. Data on demographics, disease specifics, adverse effects, and treatment were reviewed. Patients were divided into two groups: those who developed M-AS after docetaxel treatment and those who did not develop the syndrome. The two groups were compared to identify risk factors for M-AS. Effectiveness of drugs used for M-AS was evaluated. Results: Sixty-seven patients were identified as fulfilling the inclusion criteria. Nineteen patients developed the M-AS after the first docetaxel administration. Forty-eight patients did not develop the syndrome. Three patients in this group were excluded because they had been taking gabapentin or pregabalin at the time of docetaxel administration for another indication. The remaining 45 patients constituted the control group. The two groups were similar in age, menopause status, stage of their cancer, and histology. The M-AS group had a higher median body surface area and was more likely to receive less than the three intended cycles of docetaxel. Nonsteroidal anti-inflammatory drugs, atypical antiepileptics, extended corticosteroids, and opioids were drugs used as M-AS treatments. Conclusion: Docetaxel-associated M-AS is an adverse effect causing incomplete drug treatment. Possible risk factors and effectiveness of treatments for the syndrome are presented. Keywords: myalgia–arthralgia syndrome, taxanes, gabapentin, pregabalin, adverse effectshttps://www.dovepress.com/docetaxel-associated-myalgiandasharthralgia-syndrome-in-patients-with--peer-reviewed-article-BCTTMyalgia-arthralgia syndrometaxanesgabapentinpregabalinadverse effects. |
| spellingShingle | Seguin C Kovacevich N Voutsadakis IA Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer Breast Cancer: Targets and Therapy Myalgia-arthralgia syndrome taxanes gabapentin pregabalin adverse effects. |
| title | Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer |
| title_full | Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer |
| title_fullStr | Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer |
| title_full_unstemmed | Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer |
| title_short | Docetaxel-associated myalgia–arthralgia syndrome in patients with breast cancer |
| title_sort | docetaxel associated myalgia ndash arthralgia syndrome in patients with breast cancer |
| topic | Myalgia-arthralgia syndrome taxanes gabapentin pregabalin adverse effects. |
| url | https://www.dovepress.com/docetaxel-associated-myalgiandasharthralgia-syndrome-in-patients-with--peer-reviewed-article-BCTT |
| work_keys_str_mv | AT seguinc docetaxelassociatedmyalgiandasharthralgiasyndromeinpatientswithbreastcancer AT kovacevichn docetaxelassociatedmyalgiandasharthralgiasyndromeinpatientswithbreastcancer AT voutsadakisia docetaxelassociatedmyalgiandasharthralgiasyndromeinpatientswithbreastcancer |