A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis
BackgroundPreeclampsia (PE) is a specific hypertensive disorder in pregnancy. Lead (Pb) is a heavy metal that affects women's reproductive health. However, it is unclear whether lead exposure during can predispose maternal risk of developing preeclampsia. This systematic review and meta-analysi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1072052/full |
| _version_ | 1797978726069174272 |
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| author | Zixing Zhong Qingmei Yang Qingmei Yang Chu Li Xiaohong Chen Feifei Zhou |
| author_facet | Zixing Zhong Qingmei Yang Qingmei Yang Chu Li Xiaohong Chen Feifei Zhou |
| author_sort | Zixing Zhong |
| collection | DOAJ |
| description | BackgroundPreeclampsia (PE) is a specific hypertensive disorder in pregnancy. Lead (Pb) is a heavy metal that affects women's reproductive health. However, it is unclear whether lead exposure during can predispose maternal risk of developing preeclampsia. This systematic review and meta-analysis study aimed to explore the association.MethodsWe searched studies from three databases (PubMed, Web of Science, Embase). Only case-control, cross-sectional, and cohort studies reporting maternal blood lead levels (BLL) and PE were included from database inception to 31st July 2022. Pregnant women with blood lead levels measured were eligible. Those healthy pregnant women who did not develop preeclampsia were assessed as comparators. Letters, comments, case reports, and reviews were excluded. Newcastle-Ottawa Scale (NOS) and its adaptive form were applied for assessment. The random-effects method (REM) was applied to calculate the standardized mean difference (SMD) with a 95% confidence interval (CI). Stata 16.0 and RevMan 5.3 were the software used for data extraction and analysis.Results25 studies out of 1,808 articles made the finalist for systematic reviews, of which 21 underwent further quantity analysis. A total of 1,533 preeclamptic women and 10,998 healthy pregnant controls were included in the meta-analysis. The overall result revealed that maternal lead exposure was significantly higher in women with preeclampsia (SMD: 1.06, 95% CI 0.69, 1.43); (I2 = 96.40%; P = 0.000).ConclusionThis study demonstrates that maternal lead exposure is associated with preeclampsia during pregnancy. The association is present even in low blood lead levels. The conclusion should be taken seriously and women should avoid unexpected exposure to a lead-containing environment as much as possible.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=347220, identifier: CRD42022347220. |
| first_indexed | 2024-04-11T05:27:35Z |
| format | Article |
| id | doaj.art-db7b25f6d04d40fa9d3162c7c9c5c874 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T05:27:35Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-db7b25f6d04d40fa9d3162c7c9c5c8742022-12-23T05:01:01ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-12-011010.3389/fpubh.2022.10720521072052A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysisZixing Zhong0Qingmei Yang1Qingmei Yang2Chu Li3Xiaohong Chen4Feifei Zhou5Center for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaGraduate School, Bengbu Medical University, Bengbu, Anhui, ChinaCenter for Reproductive Medicine, Department of Reproductive Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, ChinaThe Second Clinical College of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Pediatrics, Central Hospital of Haining, Haining, Zhejiang, ChinaCenter for Reproductive Medicine, Department of Traditional Chinese Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, ChinaBackgroundPreeclampsia (PE) is a specific hypertensive disorder in pregnancy. Lead (Pb) is a heavy metal that affects women's reproductive health. However, it is unclear whether lead exposure during can predispose maternal risk of developing preeclampsia. This systematic review and meta-analysis study aimed to explore the association.MethodsWe searched studies from three databases (PubMed, Web of Science, Embase). Only case-control, cross-sectional, and cohort studies reporting maternal blood lead levels (BLL) and PE were included from database inception to 31st July 2022. Pregnant women with blood lead levels measured were eligible. Those healthy pregnant women who did not develop preeclampsia were assessed as comparators. Letters, comments, case reports, and reviews were excluded. Newcastle-Ottawa Scale (NOS) and its adaptive form were applied for assessment. The random-effects method (REM) was applied to calculate the standardized mean difference (SMD) with a 95% confidence interval (CI). Stata 16.0 and RevMan 5.3 were the software used for data extraction and analysis.Results25 studies out of 1,808 articles made the finalist for systematic reviews, of which 21 underwent further quantity analysis. A total of 1,533 preeclamptic women and 10,998 healthy pregnant controls were included in the meta-analysis. The overall result revealed that maternal lead exposure was significantly higher in women with preeclampsia (SMD: 1.06, 95% CI 0.69, 1.43); (I2 = 96.40%; P = 0.000).ConclusionThis study demonstrates that maternal lead exposure is associated with preeclampsia during pregnancy. The association is present even in low blood lead levels. The conclusion should be taken seriously and women should avoid unexpected exposure to a lead-containing environment as much as possible.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=347220, identifier: CRD42022347220.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1072052/fullleadPbheavy metalshypertensive disorder complicating pregnancypreeclampsia (PE)systematic review |
| spellingShingle | Zixing Zhong Qingmei Yang Qingmei Yang Chu Li Xiaohong Chen Feifei Zhou A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis Frontiers in Public Health lead Pb heavy metals hypertensive disorder complicating pregnancy preeclampsia (PE) systematic review |
| title | A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis |
| title_full | A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis |
| title_fullStr | A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis |
| title_full_unstemmed | A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis |
| title_short | A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis |
| title_sort | global perspective of correlation between maternal blood lead levels and risks of preeclampsia an updated systematic review and meta analysis |
| topic | lead Pb heavy metals hypertensive disorder complicating pregnancy preeclampsia (PE) systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1072052/full |
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