Tumor lysis syndrome in solid tumors: an up to date review of the literature
Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizur...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2014-06-01
|
| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/5389 |
| _version_ | 1818210365897441280 |
|---|---|
| author | Aibek E. Mirrakhimov Alaa M. Ali Maliha Khan Aram Barbaryan |
| author_facet | Aibek E. Mirrakhimov Alaa M. Ali Maliha Khan Aram Barbaryan |
| author_sort | Aibek E. Mirrakhimov |
| collection | DOAJ |
| description | Tumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. TLS is especially common in patients with hematological malignancies with rapid cellular turnover rates such as acute lymphocytic leukemia and Burkitt lymphoma, but is very rare in patients with solid tumors. Nevertheless, there are multiple reports in the literature on the occurrence of TLS in patients with solid tumors. In this review article, we summarize the current data on the occurrence of TLS in patients with solid tumors. We propose an algorithm of risk stratification and prevention of TLS in patients with solid cancers. |
| first_indexed | 2024-12-12T05:15:27Z |
| format | Article |
| id | doaj.art-db7d0853aa05446295a60330bc6db3fc |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-12T05:15:27Z |
| publishDate | 2014-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-db7d0853aa05446295a60330bc6db3fc2022-12-22T00:36:48ZengSAGE PublishingRare Tumors2036-36052036-36132014-06-016210.4081/rt.2014.53892833Tumor lysis syndrome in solid tumors: an up to date review of the literatureAibek E. Mirrakhimov0Alaa M. Ali1Maliha Khan2Aram Barbaryan3Department of Internal Medicine, Saint Joseph Hospital, Chicago, ILDepartment of Internal Medicine, Saint Joseph Hospital, Chicago, ILDepartment of Internal Medicine, Saint Joseph Hospital, Chicago, ILDepartment of Internal Medicine, Saint Joseph Hospital, Chicago, ILTumor lysis syndrome (TLS) is a potentially deadly complication of tumors or their treatment. This syndrome consists of a constellation of laboratory findings such as hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia, known as laboratory TLS. When clinical complications such as seizures, acute renal failure, and cardiac dysrhythmias occur in patients with laboratory TLS, the syndrome is called clinical TLS. TLS is especially common in patients with hematological malignancies with rapid cellular turnover rates such as acute lymphocytic leukemia and Burkitt lymphoma, but is very rare in patients with solid tumors. Nevertheless, there are multiple reports in the literature on the occurrence of TLS in patients with solid tumors. In this review article, we summarize the current data on the occurrence of TLS in patients with solid tumors. We propose an algorithm of risk stratification and prevention of TLS in patients with solid cancers.http://www.pagepress.org/journals/index.php/rt/article/view/5389tumor lysis syndrome, solid cancers |
| spellingShingle | Aibek E. Mirrakhimov Alaa M. Ali Maliha Khan Aram Barbaryan Tumor lysis syndrome in solid tumors: an up to date review of the literature Rare Tumors tumor lysis syndrome, solid cancers |
| title | Tumor lysis syndrome in solid tumors: an up to date review of the literature |
| title_full | Tumor lysis syndrome in solid tumors: an up to date review of the literature |
| title_fullStr | Tumor lysis syndrome in solid tumors: an up to date review of the literature |
| title_full_unstemmed | Tumor lysis syndrome in solid tumors: an up to date review of the literature |
| title_short | Tumor lysis syndrome in solid tumors: an up to date review of the literature |
| title_sort | tumor lysis syndrome in solid tumors an up to date review of the literature |
| topic | tumor lysis syndrome, solid cancers |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/5389 |
| work_keys_str_mv | AT aibekemirrakhimov tumorlysissyndromeinsolidtumorsanuptodatereviewoftheliterature AT alaamali tumorlysissyndromeinsolidtumorsanuptodatereviewoftheliterature AT malihakhan tumorlysissyndromeinsolidtumorsanuptodatereviewoftheliterature AT arambarbaryan tumorlysissyndromeinsolidtumorsanuptodatereviewoftheliterature |