Update on Biological Therapeutics for Asthma
Asthma poses a significant burden on patients, families, health care providers, and the medical system. While efforts to standardize care through guidelines have expanded, difficulty in managing severe asthma has encouraged research about its pathobiology and treatment options. Novel biologic therap...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-01-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193945511930479X |
| _version_ | 1818023916085444608 |
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| author | Marisha L. Cook, MD Bruce S. Bochner, MD |
| author_facet | Marisha L. Cook, MD Bruce S. Bochner, MD |
| author_sort | Marisha L. Cook, MD |
| collection | DOAJ |
| description | Asthma poses a significant burden on patients, families, health care providers, and the medical system. While efforts to standardize care through guidelines have expanded, difficulty in managing severe asthma has encouraged research about its pathobiology and treatment options. Novel biologic therapeutics are being developed for the treatment of asthma and are of potential use for severe refractory asthma, especially where the increased cost of such agents is more likely justified. This review will summarize currently approved (omalizumab) and investigational biologic agents for asthma, such as antibodies, soluble receptors, and other protein-based antagonists, and highlight recent published data on efficacy and safety of these therapies in humans. As these newer agents with highly targeted pharmacology are tested in asthma, we are also poised to learn more about the role of cytokines and other molecules in the pathophysiology of asthma. Keywords: asthma, biologic therapies, cytokines, monoclonal antibodies |
| first_indexed | 2024-12-10T03:51:55Z |
| format | Article |
| id | doaj.art-db7dc32cde014b3ebd0493b98899673a |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-12-10T03:51:55Z |
| publishDate | 2010-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-db7dc32cde014b3ebd0493b98899673a2022-12-22T02:03:14ZengElsevierWorld Allergy Organization Journal1939-45512010-01-0136188194Update on Biological Therapeutics for AsthmaMarisha L. Cook, MD0Bruce S. Bochner, MD1Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MDCorresponding author.; Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MDAsthma poses a significant burden on patients, families, health care providers, and the medical system. While efforts to standardize care through guidelines have expanded, difficulty in managing severe asthma has encouraged research about its pathobiology and treatment options. Novel biologic therapeutics are being developed for the treatment of asthma and are of potential use for severe refractory asthma, especially where the increased cost of such agents is more likely justified. This review will summarize currently approved (omalizumab) and investigational biologic agents for asthma, such as antibodies, soluble receptors, and other protein-based antagonists, and highlight recent published data on efficacy and safety of these therapies in humans. As these newer agents with highly targeted pharmacology are tested in asthma, we are also poised to learn more about the role of cytokines and other molecules in the pathophysiology of asthma. Keywords: asthma, biologic therapies, cytokines, monoclonal antibodieshttp://www.sciencedirect.com/science/article/pii/S193945511930479X |
| spellingShingle | Marisha L. Cook, MD Bruce S. Bochner, MD Update on Biological Therapeutics for Asthma World Allergy Organization Journal |
| title | Update on Biological Therapeutics for Asthma |
| title_full | Update on Biological Therapeutics for Asthma |
| title_fullStr | Update on Biological Therapeutics for Asthma |
| title_full_unstemmed | Update on Biological Therapeutics for Asthma |
| title_short | Update on Biological Therapeutics for Asthma |
| title_sort | update on biological therapeutics for asthma |
| url | http://www.sciencedirect.com/science/article/pii/S193945511930479X |
| work_keys_str_mv | AT marishalcookmd updateonbiologicaltherapeuticsforasthma AT brucesbochnermd updateonbiologicaltherapeuticsforasthma |