Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges
Bone metastases and osteoid osteoma (OO) have a high incidence in patients facing primary lesions in many organs. Radiotherapy has long been the standard choice for these patients, performed as stand-alone or in conjunction with surgery. However, the needs of these patients have never been fully met...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Sensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8220/21/16/5470 |
| _version_ | 1797522113657044992 |
|---|---|
| author | Francesca De Tommasi Carlo Massaroni Rosario Francesco Grasso Massimiliano Carassiti Emiliano Schena |
| author_facet | Francesca De Tommasi Carlo Massaroni Rosario Francesco Grasso Massimiliano Carassiti Emiliano Schena |
| author_sort | Francesca De Tommasi |
| collection | DOAJ |
| description | Bone metastases and osteoid osteoma (OO) have a high incidence in patients facing primary lesions in many organs. Radiotherapy has long been the standard choice for these patients, performed as stand-alone or in conjunction with surgery. However, the needs of these patients have never been fully met, especially in the ones with low life expectancy, where treatments devoted to pain reduction are pivotal. New techniques as hyperthermia treatments (HTs) are emerging to reduce the associated pain of bone metastases and OO. Temperature monitoring during HTs may significantly improve the clinical outcomes since the amount of thermal injury depends on the tissue temperature and the exposure time. This is particularly relevant in bone tumors due to the adjacent vulnerable structures (e.g., spinal cord and nerve roots). In this Review, we focus on the potential of temperature monitoring on HT of bone cancer. Preclinical and clinical studies have been proposed and are underway to investigate the use of different thermometric techniques in this scenario. We review these studies, the principle of work of the thermometric techniques used in HTs, their strengths, weaknesses, and pitfalls, as well as the strategies and the potential of improving the HTs outcomes. |
| first_indexed | 2024-03-10T08:24:50Z |
| format | Article |
| id | doaj.art-db7ffbde23d84a0a880e3e7199ffa5d4 |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-03-10T08:24:50Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-db7ffbde23d84a0a880e3e7199ffa5d42023-11-22T09:40:20ZengMDPI AGSensors1424-82202021-08-012116547010.3390/s21165470Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future ChallengesFrancesca De Tommasi0Carlo Massaroni1Rosario Francesco Grasso2Massimiliano Carassiti3Emiliano Schena4Unit of Measurements and Biomedical Instrumentations, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, ItalyUnit of Measurements and Biomedical Instrumentations, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, ItalyUnit of Interventional Radiology, School of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, ItalyUnit of Anesthesia, Intensive Care and Pain Management, School of Medicine, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, ItalyUnit of Measurements and Biomedical Instrumentations, Department of Engineering, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 00128 Rome, ItalyBone metastases and osteoid osteoma (OO) have a high incidence in patients facing primary lesions in many organs. Radiotherapy has long been the standard choice for these patients, performed as stand-alone or in conjunction with surgery. However, the needs of these patients have never been fully met, especially in the ones with low life expectancy, where treatments devoted to pain reduction are pivotal. New techniques as hyperthermia treatments (HTs) are emerging to reduce the associated pain of bone metastases and OO. Temperature monitoring during HTs may significantly improve the clinical outcomes since the amount of thermal injury depends on the tissue temperature and the exposure time. This is particularly relevant in bone tumors due to the adjacent vulnerable structures (e.g., spinal cord and nerve roots). In this Review, we focus on the potential of temperature monitoring on HT of bone cancer. Preclinical and clinical studies have been proposed and are underway to investigate the use of different thermometric techniques in this scenario. We review these studies, the principle of work of the thermometric techniques used in HTs, their strengths, weaknesses, and pitfalls, as well as the strategies and the potential of improving the HTs outcomes.https://www.mdpi.com/1424-8220/21/16/5470bone tumorsCT thermometryfiber Bragg grating sensorsfluoroptic sensorshyperthermia treatmentsMR thermometry |
| spellingShingle | Francesca De Tommasi Carlo Massaroni Rosario Francesco Grasso Massimiliano Carassiti Emiliano Schena Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges Sensors bone tumors CT thermometry fiber Bragg grating sensors fluoroptic sensors hyperthermia treatments MR thermometry |
| title | Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges |
| title_full | Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges |
| title_fullStr | Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges |
| title_full_unstemmed | Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges |
| title_short | Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges |
| title_sort | temperature monitoring in hyperthermia treatments of bone tumors state of the art and future challenges |
| topic | bone tumors CT thermometry fiber Bragg grating sensors fluoroptic sensors hyperthermia treatments MR thermometry |
| url | https://www.mdpi.com/1424-8220/21/16/5470 |
| work_keys_str_mv | AT francescadetommasi temperaturemonitoringinhyperthermiatreatmentsofbonetumorsstateoftheartandfuturechallenges AT carlomassaroni temperaturemonitoringinhyperthermiatreatmentsofbonetumorsstateoftheartandfuturechallenges AT rosariofrancescograsso temperaturemonitoringinhyperthermiatreatmentsofbonetumorsstateoftheartandfuturechallenges AT massimilianocarassiti temperaturemonitoringinhyperthermiatreatmentsofbonetumorsstateoftheartandfuturechallenges AT emilianoschena temperaturemonitoringinhyperthermiatreatmentsofbonetumorsstateoftheartandfuturechallenges |