The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis
<b>Introduction</b>: Pre-diabetes is an intermediate, asymptomatic state between normoglycaemia and the onset of type 2 diabetes mellitus (T2D). Recent reports indicate that there are sub-clinical changes observed in red blood cells during pre-diabetes. This systematic review protocol wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Methods and Protocols |
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| Online Access: | https://www.mdpi.com/2409-9279/6/1/13 |
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| author | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi |
| author_facet | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi |
| author_sort | Nomusa Christina Mzimela |
| collection | DOAJ |
| description | <b>Introduction</b>: Pre-diabetes is an intermediate, asymptomatic state between normoglycaemia and the onset of type 2 diabetes mellitus (T2D). Recent reports indicate that there are sub-clinical changes observed in red blood cells during pre-diabetes. This systematic review protocol will provide an outline of all procedures in the synthesis of the available data on the changes in red blood cell indices. <b>Methods and Analysis:</b> This protocol was prepared by adhering to the PRISMA 2015 guidelines for reporting protocols. Published clinical studies that involve observation, whether it is cross-sectional, comparative cross-sectional, case-control or cohort study designs that involve normal/non-diabetic and pre-diabetes reports were used. Additionally, this was accomplished by using clinical MeSH headings to search on MEDLINE, COCHRANE library and African Journal Online. Three reviewers (NCM, AMS & AK) screened all the results for eligibility criteria. Then, Downs and Black checklist was used to check the risk of bias. Review Manager v5.4 Forrest plot was used for meta-analysis and sensitivity analysis. Strength of evidence was then assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach (GRADE). <b>Results and Conclusion:</b> This protocol will give direction on the exploration of articles that report on changes in red blood cell indices in the pre-diabetic state. The results obtained from this protocol will further give direction on the research to be done at in the eThekwini district of South Africa. <b>Ethics and Dissemination:</b> The data that will be analyzed will be data that has already been published thus there will be no data collection from subjects. Therefore, no ethical clearance is required. <b>Registration Details</b>: This protocol has been registered with the International Prospective Registry of Systematic Reviews (PROSPERO) registration number “<b>CRD42020189080</b>” dated 05-07-2020. |
| first_indexed | 2024-03-11T08:20:38Z |
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| institution | Directory Open Access Journal |
| issn | 2409-9279 |
| language | English |
| last_indexed | 2024-03-11T08:20:38Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Methods and Protocols |
| spelling | doaj.art-db81c64549d44548b28d95c1f7013c342023-11-16T22:26:20ZengMDPI AGMethods and Protocols2409-92792023-01-01611310.3390/mps6010013The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-AnalysisNomusa Christina Mzimela0Aubrey Mbulelo Sosibo1Phikelelani Siphosethu Ngubane2Andile Khathi3School of Laboratory Medicine and Medical Science, College of Health Sciences, University of Kwa-Zulu Natal, Durban 4000, South AfricaSchool of Laboratory Medicine and Medical Science, College of Health Sciences, University of Kwa-Zulu Natal, Durban 4000, South AfricaSchool of Laboratory Medicine and Medical Science, College of Health Sciences, University of Kwa-Zulu Natal, Durban 4000, South AfricaSchool of Laboratory Medicine and Medical Science, College of Health Sciences, University of Kwa-Zulu Natal, Durban 4000, South Africa<b>Introduction</b>: Pre-diabetes is an intermediate, asymptomatic state between normoglycaemia and the onset of type 2 diabetes mellitus (T2D). Recent reports indicate that there are sub-clinical changes observed in red blood cells during pre-diabetes. This systematic review protocol will provide an outline of all procedures in the synthesis of the available data on the changes in red blood cell indices. <b>Methods and Analysis:</b> This protocol was prepared by adhering to the PRISMA 2015 guidelines for reporting protocols. Published clinical studies that involve observation, whether it is cross-sectional, comparative cross-sectional, case-control or cohort study designs that involve normal/non-diabetic and pre-diabetes reports were used. Additionally, this was accomplished by using clinical MeSH headings to search on MEDLINE, COCHRANE library and African Journal Online. Three reviewers (NCM, AMS & AK) screened all the results for eligibility criteria. Then, Downs and Black checklist was used to check the risk of bias. Review Manager v5.4 Forrest plot was used for meta-analysis and sensitivity analysis. Strength of evidence was then assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach (GRADE). <b>Results and Conclusion:</b> This protocol will give direction on the exploration of articles that report on changes in red blood cell indices in the pre-diabetic state. The results obtained from this protocol will further give direction on the research to be done at in the eThekwini district of South Africa. <b>Ethics and Dissemination:</b> The data that will be analyzed will be data that has already been published thus there will be no data collection from subjects. Therefore, no ethical clearance is required. <b>Registration Details</b>: This protocol has been registered with the International Prospective Registry of Systematic Reviews (PROSPERO) registration number “<b>CRD42020189080</b>” dated 05-07-2020.https://www.mdpi.com/2409-9279/6/1/13systematic reviewmeta-analysispre-diabetesred blood cellsinflammatory markershematologic changes |
| spellingShingle | Nomusa Christina Mzimela Aubrey Mbulelo Sosibo Phikelelani Siphosethu Ngubane Andile Khathi The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis Methods and Protocols systematic review meta-analysis pre-diabetes red blood cells inflammatory markers hematologic changes |
| title | The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis |
| title_full | The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis |
| title_fullStr | The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis |
| title_short | The Changes in Red Blood Cell Indices That Occur in Pre-Diabetic Patients of all Ethnicities from the 25–45 Years of Age: A Protocol for a Systematic Review and Meta-Analysis |
| title_sort | changes in red blood cell indices that occur in pre diabetic patients of all ethnicities from the 25 45 years of age a protocol for a systematic review and meta analysis |
| topic | systematic review meta-analysis pre-diabetes red blood cells inflammatory markers hematologic changes |
| url | https://www.mdpi.com/2409-9279/6/1/13 |
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