The effects on mucociliary clearance of prednisone associated with bronchial section
OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2012-01-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000600016 |
| _version_ | 1818247079830487040 |
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| author | Karina Andrighetti de Oliveira Braga Natalia Aparecida Nepomuceno Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pêgo-Fernandes |
| author_facet | Karina Andrighetti de Oliveira Braga Natalia Aparecida Nepomuceno Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pêgo-Fernandes |
| author_sort | Karina Andrighetti de Oliveira Braga |
| collection | DOAJ |
| description | OBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p<0.001). These parameters were normalized 30 days after the surgical procedure. Prednisone improved mucous transportability in the animals undergoing bronchial section and anastomosis at 15 and 30 days (p<0.05). CONCLUSION: Bronchial section and anastomosis decrease mucociliary clearance in the early postoperative period. Prednisone therapy improves mucus transportability in animals undergoing bronchial section and anastomosis. |
| first_indexed | 2024-12-12T14:59:00Z |
| format | Article |
| id | doaj.art-db83b42196f94ab383998700f490b8cf |
| institution | Directory Open Access Journal |
| issn | 1807-5932 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T14:59:00Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-db83b42196f94ab383998700f490b8cf2022-12-22T00:20:51ZengElsevier EspañaClinics1807-59321980-53222012-01-0167664765210.6061/clinics/2012(06)16The effects on mucociliary clearance of prednisone associated with bronchial sectionKarina Andrighetti de Oliveira BragaNatalia Aparecida NepomucenoAristides Tadeu CorreiaFabio Biscegli JatenePaulo Manuel Pêgo-FernandesOBJECTIVE: Infections have been and remain the major cause of morbidity and mortality after lung transplantation. Because mucociliary clearance plays an important role in human defense mechanisms, the influence of drugs on the mucociliary epithelium of patients undergoing lung transplantation must be examined. Prednisone is the most important corticosteroid used after lung transplantation. The aim of this study was to evaluate the effects of bronchial transection and prednisone therapy on mucociliary clearance. METHODS: A total of 120 rats were assigned to 4 groups according to surgical procedure or drug therapy: prednisone therapy (1.25 mg/kg/day); bronchial section and anastomosis + prednisone therapy (1.25 mg/kg/day); bronchial section + saline solution (2 ml/day); and saline solution (2 ml/day). After 7, 15, or 30 days, the animals were sacrificed, and the lungs were removed from the thoracic cavity. The in situ mucociliary transport velocity, ciliary beat frequency and in vitro mucus transportability were evaluated. RESULTS: Animals undergoing bronchial section surgery and anastomosis had a significant decrease in the ciliary beat frequency and mucociliary transport velocity 7 and 15 days after surgery (p<0.001). These parameters were normalized 30 days after the surgical procedure. Prednisone improved mucous transportability in the animals undergoing bronchial section and anastomosis at 15 and 30 days (p<0.05). CONCLUSION: Bronchial section and anastomosis decrease mucociliary clearance in the early postoperative period. Prednisone therapy improves mucus transportability in animals undergoing bronchial section and anastomosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000600016PrednisoneMucociliary clearanceBronchiLung transplantationImmunosuppression |
| spellingShingle | Karina Andrighetti de Oliveira Braga Natalia Aparecida Nepomuceno Aristides Tadeu Correia Fabio Biscegli Jatene Paulo Manuel Pêgo-Fernandes The effects on mucociliary clearance of prednisone associated with bronchial section Clinics Prednisone Mucociliary clearance Bronchi Lung transplantation Immunosuppression |
| title | The effects on mucociliary clearance of prednisone associated with bronchial section |
| title_full | The effects on mucociliary clearance of prednisone associated with bronchial section |
| title_fullStr | The effects on mucociliary clearance of prednisone associated with bronchial section |
| title_full_unstemmed | The effects on mucociliary clearance of prednisone associated with bronchial section |
| title_short | The effects on mucociliary clearance of prednisone associated with bronchial section |
| title_sort | effects on mucociliary clearance of prednisone associated with bronchial section |
| topic | Prednisone Mucociliary clearance Bronchi Lung transplantation Immunosuppression |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000600016 |
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