Five new sesquiterpenoids from agarwood of Aquilaria sinensis
Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2023-06-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.19.75 |
| _version_ | 1827875195511111680 |
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| author | Hong Zhou Xu-Yang Li Hong-Bin Fang He-Zhong Jiang Yong-Xian Cheng |
| author_facet | Hong Zhou Xu-Yang Li Hong-Bin Fang He-Zhong Jiang Yong-Xian Cheng |
| author_sort | Hong Zhou |
| collection | DOAJ |
| description | Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure–activity relationships (SAR). |
| first_indexed | 2024-03-12T17:03:22Z |
| format | Article |
| id | doaj.art-db83f11ed7b2490ea246628d20337387 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-03-12T17:03:22Z |
| publishDate | 2023-06-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-db83f11ed7b2490ea246628d203373872023-08-07T08:43:26ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972023-06-01191998100710.3762/bjoc.19.751860-5397-19-75Five new sesquiterpenoids from agarwood of Aquilaria sinensisHong Zhou0Xu-Yang Li1Hong-Bin Fang2He-Zhong Jiang3Yong-Xian Cheng4School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, 518055, China School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, PR China Five new eudesmane-type sesquiterpenoids (aquisinenoids F–J (1–5)) and five known compounds (6–10) were isolated from the agarwood of Aquilaria sinensis. Their structures, including absolute configurations, were identified by comprehensive spectroscopic analyses and computational methods. Inspired by our previous study on the same kinds of skeletons, we speculated that the new compounds have anticancer and anti-inflammatory activities. The results did not show any activity, but they revealed the structure–activity relationships (SAR).https://doi.org/10.3762/bjoc.19.75agarwoodaquilaria sinensissar studiessesquiterpenoids |
| spellingShingle | Hong Zhou Xu-Yang Li Hong-Bin Fang He-Zhong Jiang Yong-Xian Cheng Five new sesquiterpenoids from agarwood of Aquilaria sinensis Beilstein Journal of Organic Chemistry agarwood aquilaria sinensis sar studies sesquiterpenoids |
| title | Five new sesquiterpenoids from agarwood of Aquilaria sinensis |
| title_full | Five new sesquiterpenoids from agarwood of Aquilaria sinensis |
| title_fullStr | Five new sesquiterpenoids from agarwood of Aquilaria sinensis |
| title_full_unstemmed | Five new sesquiterpenoids from agarwood of Aquilaria sinensis |
| title_short | Five new sesquiterpenoids from agarwood of Aquilaria sinensis |
| title_sort | five new sesquiterpenoids from agarwood of aquilaria sinensis |
| topic | agarwood aquilaria sinensis sar studies sesquiterpenoids |
| url | https://doi.org/10.3762/bjoc.19.75 |
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